Effect of aluminum hydroxide on diflunisal absorption
1 The effect of aluminum hydroxide on the oral absorption of diflunisal was studied in healthy subjects. 2 Relative bioavailability of the oral diflunisal dose (500 mg) was estimated by comparison of the areas under plasma concentration versus time curves, and comparison of the amount of drug (uncha...
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| Published in | British journal of clinical pharmacology Vol. 7; no. 5; pp. 519 - 522 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Publishing Ltd
01.05.1979
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0306-5251 1365-2125 |
| DOI | 10.1111/j.1365-2125.1979.tb00997.x |
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| Abstract | 1 The effect of aluminum hydroxide on the oral absorption of diflunisal was studied in healthy subjects. 2 Relative bioavailability of the oral diflunisal dose (500 mg) was estimated by comparison of the areas under plasma concentration versus time curves, and comparison of the amount of drug (unchanged + glucuronides) excreted in the urine. 3 From the AUC‐method, a relative bioavailability of 0.60 was calculated. A similar value (F = 0.63) was obtained from the urinary excretion data. 4 The results indicate that co‐administration of aluminum hydroxide reduces the bioavailability of oral diflusinal by about 40%. |
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| AbstractList | 1 The effect of aluminum hydroxide on the oral absorption of diflunisal was studied in healthy subjects. 2 Relative bioavailability of the oral diflunisal dose (500 mg) was estimated by comparison of the areas under plasma concentration versus time curves, and comparison of the amount of drug (unchanged + glucuronides) excreted in the urine. 3 From the AUC-method, a relative bioavailability of 0.60 was calculated. A similar value (F = 0.63) was obtained from the urinary excretion data. 4 The results indicate that co-administration of aluminum hydroxide reduces the bioavailability of oral diflusinal by about 40%. 1 The effect of aluminum hydroxide on the oral absorption of diflunisal was studied in healthy subjects. 2 Relative bioavailability of the oral diflunisal dose (500 mg) was estimated by comparison of the areas under plasma concentration versus time curves, and comparison of the amount of drug (unchanged + glucuronides) excreted in the urine. 3 From the AUC-method, a relative bioavailability of 0.60 was calculated. A similar value (F = 0.63) was obtained from the urinary excretion data. 4 The results indicate that co-administration of aluminum hydroxide reduces the bioavailability of oral diflusinal by about 40%.1 The effect of aluminum hydroxide on the oral absorption of diflunisal was studied in healthy subjects. 2 Relative bioavailability of the oral diflunisal dose (500 mg) was estimated by comparison of the areas under plasma concentration versus time curves, and comparison of the amount of drug (unchanged + glucuronides) excreted in the urine. 3 From the AUC-method, a relative bioavailability of 0.60 was calculated. A similar value (F = 0.63) was obtained from the urinary excretion data. 4 The results indicate that co-administration of aluminum hydroxide reduces the bioavailability of oral diflusinal by about 40%. |
| Author | Mullie, A Schepper, PJ Tjandramaga, TB Verbeeck, R Verbesselt, R |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/314299$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/S0090-9556(25)05767-8 10.2165/00003088-197601030-00002 10.2165/00003088-197702040-00003 10.2165/00003088-197702010-00004 10.1111/j.1365-2125.1974.tb00234.x 10.1111/j.1365-2125.1979.tb00932.x 10.1007/BF00587768 |
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| References | 1976; 31 1974 1974; 1 1977; 2 1976; 1 1973; 7 1975; 3 1977; 297 1979; 7 e_1_2_1_7_1 e_1_2_1_8_1 e_1_2_1_5_1 e_1_2_1_6_1 Tocco D.J. (e_1_2_1_9_1) 1975; 3 e_1_2_1_3_1 e_1_2_1_11_1 Khalil S.A.H. (e_1_2_1_4_1) 1976; 31 Hurwitz A. (e_1_2_1_2_1) 1974 Vats T.S. (e_1_2_1_10_1) 1973; 7 |
| References_xml | – year: 1974 – volume: 7 start-page: 112 year: 1973 end-page: 000 article-title: Effects of antacids on gastric emptying in children publication-title: Pediat. Res. – volume: 31 start-page: 105 year: 1976 end-page: 109 article-title: The in vitro adsorption of some antibiotics on antacids publication-title: Pharmazie – volume: 297 start-page: S29 year: 1977 end-page: S31 article-title: Drug interaction during absorption publication-title: Naunyn-Schmiedebergs Arch. Pharmac. – volume: 1 start-page: 189 year: 1974 end-page: 190 article-title: Gastric emptying and drug absorption publication-title: Br. J. clin. Pharmac. – volume: 7 start-page: 273 year: 1979 end-page: 282 article-title: Biotransformation of diflunisal and renal excretion of its glucuronides in renal insufficiency publication-title: Br. J. clin. Pharmac. – volume: 1 start-page: 189 year: 1976 end-page: 203 article-title: Drugs, diseases and altered gastric emptying publication-title: Clin. Pharmacokin – volume: 3 start-page: 453 year: 1975 end-page: 466 article-title: Physiological disposition and metabolism of 5‐(2′,4′‐difluorophenyl) salicylic acid, a new salicylate publication-title: Drug Met. Disp. – volume: 2 start-page: 45 year: 1977 end-page: 60 article-title: Drug absorption in gastrointestinal disease with particular reference to malabsorption syndromes publication-title: Clin. Pharmacokin – volume: 2 start-page: 269 year: 1977 end-page: 280 article-title: Antacid therapy and drug kinetics publication-title: Clin. Pharmacokin – volume: 3 start-page: 453 year: 1975 ident: e_1_2_1_9_1 article-title: Physiological disposition and metabolism of 5‐(2′,4′‐difluorophenyl) salicylic acid, a new salicylate publication-title: Drug Met. Disp. doi: 10.1016/S0090-9556(25)05767-8 – ident: e_1_2_1_5_1 doi: 10.2165/00003088-197601030-00002 – ident: e_1_2_1_3_1 doi: 10.2165/00003088-197702040-00003 – volume: 31 start-page: 105 year: 1976 ident: e_1_2_1_4_1 article-title: The in vitro adsorption of some antibiotics on antacids publication-title: Pharmazie – ident: e_1_2_1_6_1 doi: 10.2165/00003088-197702010-00004 – volume: 7 start-page: 112 year: 1973 ident: e_1_2_1_10_1 article-title: Effects of antacids on gastric emptying in children publication-title: Pediat. Res. – ident: e_1_2_1_7_1 doi: 10.1111/j.1365-2125.1974.tb00234.x – volume-title: Drug Interactions year: 1974 ident: e_1_2_1_2_1 – ident: e_1_2_1_11_1 doi: 10.1111/j.1365-2125.1979.tb00932.x – ident: e_1_2_1_8_1 doi: 10.1007/BF00587768 |
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| SubjectTerms | Aluminum Hydroxide - pharmacology Anti-Inflammatory Agents, Non-Steroidal - blood Anti-Inflammatory Agents, Non-Steroidal - metabolism Anti-Inflammatory Agents, Non-Steroidal - urine Biological Availability Humans Intestinal Absorption - drug effects Kinetics Male Salicylates - blood Salicylates - metabolism Salicylates - urine Time Factors |
| Title | Effect of aluminum hydroxide on diflunisal absorption |
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