Effect of aluminum hydroxide on diflunisal absorption

1 The effect of aluminum hydroxide on the oral absorption of diflunisal was studied in healthy subjects. 2 Relative bioavailability of the oral diflunisal dose (500 mg) was estimated by comparison of the areas under plasma concentration versus time curves, and comparison of the amount of drug (uncha...

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Bibliographic Details
Published inBritish journal of clinical pharmacology Vol. 7; no. 5; pp. 519 - 522
Main Authors Verbeeck, R, Tjandramaga, TB, Mullie, A, Verbesselt, R, Schepper, PJ
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.05.1979
Subjects
Aluminum Hydroxide - pharmacology
Anti-Inflammatory Agents, Non-Steroidal - blood
Anti-Inflammatory Agents, Non-Steroidal - metabolism
Anti-Inflammatory Agents, Non-Steroidal - urine
Biological Availability
Humans
Intestinal Absorption - drug effects
Kinetics
Male
Salicylates - blood
Salicylates - metabolism
Salicylates - urine
Time Factors
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ISSN0306-5251
1365-2125
DOI10.1111/j.1365-2125.1979.tb00997.x

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Summary:1 The effect of aluminum hydroxide on the oral absorption of diflunisal was studied in healthy subjects. 2 Relative bioavailability of the oral diflunisal dose (500 mg) was estimated by comparison of the areas under plasma concentration versus time curves, and comparison of the amount of drug (unchanged + glucuronides) excreted in the urine. 3 From the AUC‐method, a relative bioavailability of 0.60 was calculated. A similar value (F = 0.63) was obtained from the urinary excretion data. 4 The results indicate that co‐administration of aluminum hydroxide reduces the bioavailability of oral diflusinal by about 40%.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0306-5251
1365-2125
DOI:10.1111/j.1365-2125.1979.tb00997.x