Circulating bone morphogenetic protein-9 in relation to metabolic syndrome and insulin resistance

• Published in: Scientific reports Vol. 7; no. 1; pp. 17529 - 7
• Main Authors: Xu, Xiaohui, Li, Xiaoqiang, Yang, Gangyi, Li, Ling, Hu, Wenjing, Zhang, Lili, Liu, Hua, Zheng, Hongting, Tan, Minghong, Zhu, Danping
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 13.12.2017; Nature Publishing Group
• Subjects: 13/21; 692/163/2743/2037; 692/163/2743/2099; 82/51; 82/80; Blood; Blood glucose; Bone morphogenetic protein 9; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Enzyme-linked immunosorbent assay; Glucose; High density lipoprotein; Hip; Humanities and Social Sciences; Insulin; Insulin resistance; Metabolic disorders; Metabolic syndrome; multidisciplinary; Science; Science (multidisciplinary)
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-017-17807-y

Our objective is to determine circulating Bone morphogenetic protein-9(BMP-9) levels in subjects with Metabolic Syndrome (MetS) and examine the relationship between BMP-9 and conventional markers for MetS and insulin resistance (IR). A total of 362 newly diagnosed patients with MetS along with healthy controls were recruited for this cross-sectional study. Circulating BMP-9 levels were measured by ELISA. Circulating BMP-9 levels were significantly lower in MetS patients compared to those of the healthy controls. BMP-9 was associated negatively with Waist hip ratio (WHR), fasting blood glucose (FBG), 2-hour blood glucose after glucose overload (2h-OGTT), HbA1c, triglyceride (TG) levels and HOMA-IR and positively with free fatty acid (FFA) and HDL after control for age and sex. In a multiple linear regression, BMP-9 was independently associated with type 2 diabetes mellitus (T2DM), HOMA-IR and FFA. Binary logistic regression showed that plasma BMP-9 concentrations were significantly associated with MetS even after controlling for anthropometric variables and lipid profiles. In addition, circulating BMP-9 levels reduced progressively with an increasing number of MetS components. The best cutoff values for circulating BMP-9 to predict MetS was 56.6 ng/L. Circulating BMP-9 levels were associated with the key components of MetS and IR.