The Role of Periostin in the Occurrence and Progression of Eosinophilic Chronic Sinusitis with Nasal Polyps

• Published in: Scientific reports Vol. 7; no. 1; pp. 9479 - 9
• Main Authors: Xu, Ming, Chen, Daishi, Zhou, Haojie, Zhang, Weiwei, Xu, Jun, Chen, Lei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 25.08.2017; Nature Publishing Group
• Subjects: 13; 13/1; 13/106; 13/109; 13/51; 13/89; 631/250/127/98; 631/337/505; 96/21; Adult; Aged; Cell Adhesion Molecules - genetics; Cell Adhesion Molecules - metabolism; Chemokine CCL5 - genetics; Chemokine CCL5 - metabolism; Chronic Disease; Disease Progression; Disease Susceptibility; Eosinophilia - pathology; Eotaxin; Female; Fibroblasts; Fibroblasts - metabolism; Gene Expression Regulation; Gene Knockdown Techniques; Humanities and Social Sciences; Humans; Leukocytes (eosinophilic); Male; Middle Aged; multidisciplinary; Nasal Polyps - pathology; Nose; Polyps; RANTES; Rhinosinusitis; Risk Factors; RNA, Small Interfering - genetics; Science; Science (multidisciplinary); Sinusitis - etiology; Sinusitis - pathology; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - genetics; Vascular Endothelial Growth Factor A - metabolism; Young Adult
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-017-08375-2

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a highly heterogeneous disease with different host defence responses. However, whether periostin and vascular endothelial growth factor (VEGF) are similarly impaired in patients with eosinophilic CRSwNP (ENP) and those with non-eosinophilic CRSwNP (nENP) remains unclear. We sought to evaluate the expression and possible modulation of periostin and VEGF, regulated on activation normal T expressed and secreted (RANTES) and eotaxin-2 in the polyp tissues from 30 patients with ENP and from 36 patients with nENP and in middle turbinate tissues from 12 control subjects. We found that ENP tissues exhibited a significantly increased expression of periostin and VEGF compared with tissues from patients with nENP and control subjects ( P  < 0.05, respectively). Accordingly, the expression of VEGF, RANTES, and eotaxin-2 in ENP fibroblasts was significantly up-regulated after stimulation with up-regulated periostin in vitro , but the expression of VEGF and RANTES was significantly inhibited by stimulation with down-regulated periostin. Our findings suggest that periostin might play an important role in the occurrence and progression of ENP and might be a potential therapeutic target.