Reduction in Bile Acid Pool Causes Delayed Liver Regeneration Accompanied by Down-regulated Expression of FXR and C-Jun mRNA in Rats

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences Vol. 30; no. 1; pp. 55 - 60
• Main Author: 董秀山 赵浩亮 马晓明 王世明
• Format: Journal Article
• Language: English
• Published: Heidelberg Huazhong University of Science and Technology 01.02.2010; The First Hospital of Shanxi Medical University,Taiyuan 030001,China
• Subjects: Animals; Bile Acids and Salts - administration & dosage; Bile Acids and Salts - pharmacology; Cholestyramine Resin - administration & dosage; Cholestyramine Resin - pharmacology; Down-Regulation; Hepatectomy - methods; Liver Regeneration - drug effects; Male; Medicine; Medicine & Public Health; Proto-Oncogene Proteins c-jun - genetics; Proto-Oncogene Proteins c-jun - metabolism; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear - genetics; Receptors, Cytoplasmic and Nuclear - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; c-jun; bile acids; farnesoid X receptor; liver regeneration; farnesoid Ⅹ receptor
• ISSN: 1672-0733; 1993-1352
• DOI: 10.1007/s11596-010-0110-8

The present study attempted to examine the effects of bile acid pool size on liver regeneration after hepatectomy.The rats were fed on 0.2% cholic acid(CA)or 2% cholestyramine for 7 days to induce a change in the bile acid size,and then a partial hepatectomy(PH)was performed.Rats fed on the normal diet served as the controls.Measurements were made on the rate of liver regeneration,the labeling indices of PCNA,the plasma total bile acids(TBA),and the mRNA expression of cholesterol 7alpha-hydroxylase(CYP7A1),...