Does hemispheric vascular regulation differ significantly in glaucoma patients with altitudinal visual field asymmetry? A single-center, prospective study

• Published in: International ophthalmology Vol. 41; no. 9; pp. 3109 - 3119
• Main Authors: Kuerten, David, Kotliar, Konstantin, Fuest, Matthias, Walter, Peter, Hollstein, Muriel, Plange, Niklas
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.09.2021; Springer Nature B.V
• Subjects: Arteries; Asymmetry; Blood vessels; Diameters; Eye (anatomy); Flicker; Glaucoma; Glaucoma - diagnosis; Glaucoma, Open-Angle; Hemispheres; Hemispheric laterality; Humans; Intraocular Pressure; Medicine; Medicine & Public Health; Ophthalmology; Original Paper; Pathogenesis; Perfusion; Pilot Projects; Prospective Studies; Retina; Retinal Vessels; Risk analysis; Risk factors; Veins; Veins & arteries; Visual field; Visual Field Tests; Visual Fields; Glaucoma; RVA; Ocular blood flow; Visual field asymmetry; Vascular response; Neurovascular coupling
• ISSN: 0165-5701; 1573-2630; 1573-2630
• DOI: 10.1007/s10792-021-01876-0

Purpose Vascular risk factors and ocular perfusion are heatedly discussed in the pathogenesis of glaucoma. The retinal vessel analyzer (RVA, IMEDOS Systems, Germany) allows noninvasive measurement of retinal vessel regulation. Significant differences especially in the veins between healthy subjects and patients suffering from glaucoma were previously reported. In this pilot-study we investigated if localized vascular regulation is altered in glaucoma patients with altitudinal visual field defect asymmetry. Methods 15 eyes of 12 glaucoma patients with advanced altitudinal visual field defect asymmetry were included. The mean defect was calculated for each hemisphere separately (−20.99 ± 10.49 profound hemispheric visual field defect vs −7.36 ± 3.97 dB less profound hemisphere). After pupil dilation, RVA measurements of retinal arteries and veins were conducted using the standard protocol. The superior and inferior retinal vessel reactivity were measured consecutively in each eye. Results Significant differences were recorded in venous vessel constriction after flicker light stimulation and overall amplitude of the reaction ( p  < 0.04 and p  < 0.02 respectively) in-between the hemispheres. Vessel reaction was higher in the hemisphere corresponding to the more advanced visual field defect. Arterial diameters reacted similarly, failing to reach statistical significance. Conclusion Localized retinal vessel regulation is significantly altered in glaucoma patients with asymmetric altitudinal visual field defects. Veins supplying the hemisphere concordant to a less profound visual field defect show diminished diameter changes. Vascular dysregulation might be particularly important in early glaucoma stages prior to a significant visual field defect.