Cardiac magnetic resonance T2 mapping and feature tracking in athlete’s heart and HCM

• Published in: European radiology Vol. 31; no. 5; pp. 2768 - 2777
• Main Authors: Gastl, Mareike, Lachmann, Vera, Christidi, Aikaterini, Janzarik, Nico, Veulemans, Verena, Haberkorn, Sebastian, Holzbach, Leonie, Jacoby, Christoph, Schnackenburg, Bernhard, Berrisch-Rahmel, Susanne, Zeus, Tobias, Kelm, Malte, Bönner, Florian
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.05.2021; Springer Nature B.V
• Subjects: Athletes; Auditory discrimination; Cardiac; Cardiomegaly, Exercise-Induced; Cardiomyopathy; Cardiomyopathy, Hypertrophic - diagnostic imaging; Deformation; Diagnostic Radiology; Heart; Heart Ventricles - diagnostic imaging; Humans; Hypertrophy; Hypertrophy, Left Ventricular - diagnostic imaging; Imaging; Internal Medicine; Interventional Radiology; Magnetic resonance imaging; Magnetic Resonance Spectroscopy; Mapping; Medical imaging; Medicine; Medicine & Public Health; Neuroradiology; Parameters; Radiology; Resonance; Risk assessment; Septum; Ultrasound; Ventricle; Multiparametric magnetic resonance imaging; Cardiomyopathy, hypertrophic; Athletes; Left ventricular; Hypertrophy
• ISSN: 0938-7994; 1432-1084; 1432-1084
• DOI: 10.1007/s00330-020-07289-4

Objectives Distinguishing hypertrophic cardiomyopathy (HCM) from left ventricular hypertrophy (LVH) due to systematic training (athlete’s heart, AH) from morphologic assessment remains challenging. The purpose of this study was to examine the role of T2 mapping and deformation imaging obtained by cardiovascular magnetic resonance (CMR) to discriminate AH from HCM with (HOCM) or without outflow tract obstruction (HNCM). Methods Thirty-three patients with HOCM, 9 with HNCM, 13 strength-trained athletes as well as individual age- and gender-matched controls received CMR. For T2 mapping, GRASE-derived multi-echo images were obtained and analyzed using dedicated software. Besides T2 mapping analyses, left ventricular (LV) dimensional and functional parameters were obtained including LV mass per body surface area (LVMi), interventricular septum thickness (IVS), and global longitudinal strain (GLS). Results While LVMi was not significantly different, IVS was thickened in HOCM patients compared to athlete’s. Absolute values of GLS were significantly increased in patients with HOCM/HNCM compared to AH. Median T2 values were elevated compared to controls except in athlete’s heart. ROC analysis revealed T2 values (AUC 0.78) and GLS (AUC 0.91) as good parameters to discriminate AH from overall HNCM/HOCM. Conclusion Discrimination of pathologic from non-pathologic LVH has implications for risk assessment of competitive sports in athletes. Multiparametric CMR with parametric T2 mapping and deformation imaging may add information to distinguish AH from LVH due to HCM. Key Points • Structural analyses using T2 mapping cardiovascular magnetic resonance imaging (CMR) may help to further distinguish myocardial diseases. • To differentiate pathologic from non-pathologic left ventricular hypertrophy, CMR including T2 mapping was obtained in patients with hypertrophic obstructive/non-obstructive cardiomyopathy (HOCM/HNCM) as well as in strength-trained athletes. • Elevated median T2 values in HOCM/HNCM compared with athlete’s may add information to distinguish athlete’s heart from pathologic left ventricular hypertrophy.