Development of wirelessly-powered, extracranial brain activator (ECBA) in a large animal model for the future non-invasive human neuromodulation

• Published in: Scientific reports Vol. 9; no. 1; pp. 10906 - 10
• Main Authors: Lee, Hyungwoo, Lee, Jin San, Chung, Yeongu, Chung, Woo Ram, Kim, Sang Joon, Kang, Joon Seong, Park, Sung Min, Kang, Wonok, Seo, Dae Won, Na, Duk L., Shon, Young-Min
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 29.07.2019; Nature Publishing Group
• Subjects: 631/378/3920; 692/617/375/1399; Animal models; Animals; Brain research; Cerebral Cortex - surgery; Dogs; Electric currents; Electrical stimuli; Electrocorticography - instrumentation; Electrodes; Humanities and Social Sciences; Implantable Neurostimulators; Male; multidisciplinary; Neuromodulation; Science; Science (multidisciplinary); Skin; Surgery; Transcranial Direct Current Stimulation - instrumentation; Wireless Technology
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-019-47383-2

As transcranial electrical stimulation (tES) is an emerging and promising technique for neuromodulation, we developed a novel device; wirelessly-powered, extracranial brain activator (ECBA), which is mounted subcutaneously, and its neuromodulation effect was investigated. The oscillatory changes in electrocorticography (EcoG) were analyzed from two types of stimulation. Two weeks prior to the recording experiment, we underwent surgery for implantation of subdural strips and ECBA module over centroparietal regions of anesthetized beagles. Low-frequency stimulation (LFS) and subsequent high-frequency stimulation (HFS) protocols (600 pulses respectively) were applied. Then, the power changes before and after each stimulation in five different bands were compared. A significantly larger voltage difference with subcutaneous than transcutaneous stimulation measured at EcoG channels indicated a substantial current attenuation between the skin and skull. Compared with the baseline, all subjects showed consistently decreased delta power and increased gamma power after HFS. LFS also induced a similar, but opposite, pattern of power change in four beagles. The results from this study indicate that LFS and HFS with our novel ECBA can consistently and effectively modulate neural activity of the cortex, inducing neural inhibition and facilitation functions, respectively. Future studies are necessary to further ensuring a consistent efficacy and long-term safety.