Histological Variants of Papillary Thyroid Cancer in Relation to Clinical and Morphological Parameters and Prognosis

• Published in: Bulletin of experimental biology and medicine Vol. 174; no. 5; pp. 647 - 652
• Main Authors: Ivanov, A. A., Bakarev, M. A., Lushnikova, E. L.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.03.2023; Springer; Springer Nature B.V
• Subjects: Biomedical and Life Sciences; Biomedicine; Carcinoma, Papillary - diagnosis; Carcinoma, Papillary - pathology; Case-Control Studies; Cell Biology; Cell size; Health aspects; Humans; Internal Medicine; Laboratory Medicine; Lymph nodes; Lymph Nodes - pathology; Male; Medical prognosis; Medical research; Medicine, Experimental; Metastases; Metastasis; Morphology; Mortality; Papillary thyroid cancer; Pathology; Prognosis; Thyroid cancer; Thyroid Cancer, Papillary; Thyroid Neoplasms - pathology; tall cell variant; histological variants; solid variant; prognosis of postoperative survival; papillary thyroid cancer
• ISSN: 0007-4888; 1573-8221; 1573-8221
• DOI: 10.1007/s10517-023-05762-w

The correlation of histological features of papillary thyroid cancer with clinical and morphological prognostic factors and cause-specific mortality was analyzed in a case-control study within a cohort of patients from the Altai Regional Oncology Center (25 cases with lethal outcome and 64 follow-up controls). Significant variability was revealed in the histological structure of papillary thyroid cancer with the prevalence of classic (62%) and less frequent follicular (19%), tall cell (8%), and solid (7%) variants. In comparison with the classic variant, the solid variant was more often associated with male sex and large tumor size; follicular and tall cell variant was associated with more frequent metastases to regional lymph nodes; follicular and solid variants were associated with an increased proportion of cases with disease stages III-IV. The main differences reflecting the effect of histological factor on the disease outcome were associated with the solid variant of papillary thyroid cancer that was detected in 21% of lethal cases and only in 2% of control subjects. The detection of this variant can be of importance as an additional prognostic factor of the postoperative survival in papillary thyroid cancer.