A Fermented Milk Product with B. lactis CNCM I-2494 and Lactic Acid Bacteria Improves Gastrointestinal Comfort in Response to a Challenge Diet Rich in Fermentable Residues in Healthy Subjects

• Published in: Nutrients Vol. 12; no. 2; p. 320
• Main Authors: Le Nevé, Boris, Martinez-De la Torre, Adrian, Tap, Julien, Derrien, Muriel, Cotillard, Aurélie, Barba, Elizabeth, Mego, Marianela, Nieto Ruiz, Adoración, Hernandez-Palet, Laura, Dornic, Quentin, Faurie, Jean-Michel, Butler, John, Merino, Xavi, Lobo, Beatriz, Pinsach Batet, Ferran, Accarino, Anna, Pozuelo, Marta, Manichanh, Chaysavanh, Azpiroz, Fernando
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.01.2020; MDPI
• Subjects: Abdomen; Bacteria; Bifidobacterium animalis subsp. lactis; design; Diet; fermented milk; flatulence; Food; Food and Nutrition; Gases; gastrointestinal system; Human health and pathology; Hépatology and Gastroenterology; Irritable bowel syndrome; lactic acid bacteria; Legumes; Life Sciences; Metabolism; Microbiology and Parasitology; Microbiota; Milk; nutrients; plant-based diet; Probiotics; Questionnaires; sensation; Studies; volume; Well being; fermentable carbohydrates; microbiota; digestive symptoms; flatulence; probiotics
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu12020320

Background: Healthy plant-based diets rich in fermentable residues may induce gas-related symptoms. Our aim was to determine the potential of a fermented milk product with probiotics in improving digestive comfort with such diets. Methods: In an open design, a 3-day high-residue diet was administered to healthy subjects (n = 74 included, n = 63 completed) before and following 28 days consumption of a fermented milk product (FMP) containing Bifidobacterium animalis subsp. lactis CNCM I-2494 and lactic acid bacteria. Main outcomes: digestive sensations, number of daytime anal gas evacuations, and gas volume evacuated during 4 h after a probe meal. Results: As compared to the habitual diet, the high-residue diet induced gas-related symptoms (flatulence score 4.9 vs. 1.2; p ≤ 0.0001), increased the daily number of anal gas evacuations (20.7 vs. 8.7; p < 0.0001), and impaired digestive well-being (1.0 vs. 3.4; p < 0.05). FMP consumption reduced flatulence sensation (by −1.7 [−1.9; −1.6]; p < 0.0001), reduced the number of daily evacuations (by −5.8 [−6.5; −5.1]; p < 0.0001), and improved digestive well-being (by +0.6 [+0.4; +0.7]; p < 0.05). FMP consumption did not affect the gas volume evacuated after a probe meal. Conclusion: In healthy subjects, consumption of a FMP containing B. lactis CNCM I-2494 and lactic acid bacteria improves the tolerance of a flatulogenic diet by subjective and objective criteria (sensations and number of anal gas evacuations, respectively).