Mutual Information based hybrid model and deep learning for Acute Lymphocytic Leukemia detection in single cell blood smear images

• Published in: Computer methods and programs in biomedicine Vol. 179; p. 104987
• Main Authors: Jha, Krishna Kumar, Dutta, Himadri Sekhar
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.10.2019
• Subjects: Acute Lymphocytic Leukemia; Algorithms; Databases, Factual - statistics & numerical data; Deep Learning; Deep learning classifier; Fuzzy C means algorithm; Fuzzy Logic; Humans; Image Interpretation, Computer-Assisted - statistics & numerical data; Leukocytes - pathology; Mutual Information; Neural Networks, Computer; Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood; Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnostic imaging; Sine Cosine Algorithm; Single-Cell Analysis - statistics & numerical data; Mutual Information; Fuzzy C means algorithm; Sine Cosine Algorithm; Acute Lymphocytic Leukemia; Deep learning classifier
• ISSN: 0169-2607; 1872-7565; 1872-7565
• DOI: 10.1016/j.cmpb.2019.104987

•Here, two novel approaches are designed, each for the segmentation and the classification of the leukemia cells.•Here, the chronological SCA algorithm is developed by modifying SCA and is used for selecting the optimal weights for the Deep CNN.•Proposed Chronological SCA-based Deep CNN classifier has comparatively improved performance with the accuracy of 0.987. Due to the development in digital microscopic imaging, image processing and classification has become an interesting area for diagnostic research. Various techniques are available in the literature for the detection of Acute Lymphocytic Leukemia from the single cell blood smear images. The purpose of this work is to develop an effective method for leukemia detection. This work has developed deep learning based leukemia detection module from the blood smear images. Here, the detection scheme carries out pre-processing, segmentation, feature extraction and classification. The segmentation is done by the proposed Mutual Information (MI) based hybrid model, which combines the segmentation results of the active contour model and fuzzy C means algorithm. Then, from the segmented images, the statistical and the Local Directional Pattern (LDP) features are extracted and provided to the proposed Chronological Sine Cosine Algorithm (SCA) based Deep CNN classifier for the classification. For the experimentation, the blood smear images are considered from the AA-IDB2 database and evaluated based on metrics, such as True Positive Rate (TPR), True Negative Rate (TNR), and accuracy. Simulation results reveal that the proposed Chronological SCA based Deep CNN classifier has the accuracy of 98.7%. The performance of the proposed Chronological SCA-based Deep CNN classifier is compared with the state-of-the-art methods. The analysis shows that the proposed classifier has comparatively improved performance and determines the leukemia from the blood smear images.