Delayed cortical bone healing due to impaired nuclear Nrf2 translocation in COPD mice

The effect of the pathogenesis of chronic obstructive pulmonary disease (COPD) on bone fracture healing is unknown. Oxidative stress has been implicated in the systemic complications of COPD, and decreased activity of Nrf2 signaling, a central component of the in vivo antioxidant mechanism, has been...

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Published inBone (New York, N.Y.) Vol. 173; p. 116804
Main Authors Nabeshima, Takayuki, Tsukamoto, Manabu, Wang, Ke-Yong, Mano, Yosuke, Arakawa, Daisuke, Kosugi, Kenji, Tajima, Takafumi, Yamanaka, Yoshiaki, Suzuki, Hitoshi, Kawasaki, Makoto, Uchida, Soshi, Nakamura, Eiichiro, Azuma, Kagaku, Sakai, Akinori
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.08.2023
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ISSN8756-3282
1873-2763
1873-2763
DOI10.1016/j.bone.2023.116804

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Summary:The effect of the pathogenesis of chronic obstructive pulmonary disease (COPD) on bone fracture healing is unknown. Oxidative stress has been implicated in the systemic complications of COPD, and decreased activity of Nrf2 signaling, a central component of the in vivo antioxidant mechanism, has been reported. We investigated the process of cortical bone repair in a mouse model of elastase-induced emphysema by creating a drill hole and focusing on Nrf2 and found that the amount of new bone in the drill hole was reduced and bone formation capacity was decreased in the model mice. Furthermore, nuclear Nrf2 expression in osteoblasts was reduced in model mice. Sulforaphane, an Nrf2 activator, improved delayed cortical bone healing in model mice. This study indicates that bone healing is delayed in COPD mice and that impaired nuclear translocation of Nrf2 is involved in delayed cortical bone healing, suggesting that Nrf2 may be a novel target for bone fracture treatment in COPD patients. •Elastase-induced pulmonary emphysema mice were showed delayed cortical bone healing.•Bone healing was delayed due to impaired bone formation capacity in the model mice.•Nrf2 expression in nucleus of osteoblasts located in new bone was declined.•Administration of sulforaphane, an Nrf2 activator, ameliorated delayed bone healing.•Impaired nuclear Nrf2 translocation was involved in delayed bone healing in the mice.
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ISSN:8756-3282
1873-2763
1873-2763
DOI:10.1016/j.bone.2023.116804