Validation of Group B Borderline Resectable Pancreatic Cancer: Retrospective Analysis
Among borderline resectable pancreatic cancer (BRPC), group B BRPC patients have findings that are suggestive but not diagnostic of metastasis. In this study, we attempted to validate whether group B could truly be categorized as a borderline resectable group. We placed the BRPC patients into group...
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Published in | Gut and liver Vol. 8; no. 5; pp. 557 - 562 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Korea (South)
Gut and Liver
01.09.2014
Gastroenterology Council for Gut and Liver 거트앤리버 소화기연관학회협의회 |
Subjects | |
Online Access | Get full text |
ISSN | 1976-2283 2005-1212 2005-1212 |
DOI | 10.5009/gnl13264 |
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Summary: | Among borderline resectable pancreatic cancer (BRPC), group B BRPC patients have findings that are suggestive but not diagnostic of metastasis. In this study, we attempted to validate whether group B could truly be categorized as a borderline resectable group.
We placed the BRPC patients into group A or group B. The survival outcomes were compared between the groups.
A total of 53 patients with pancreatic adenocarcinoma was classified as either group A or B borderline resectable. In group A, 23 (60.5%) of 38 patients underwent pancreatectomy after concurrent chemoradiotherapy or chemotherapy, but in group B, only five (33.3%) of 15 patients underwent pancreatectomy, mainly because of the progression of suspected distant metastasis. There was a significant difference in overall survival (OS) between group A and B patients (median OS, 21.2 months vs 10.2 months, respectively; p=0.007). Of the patients who underwent pancreatectomy, group B had a higher recurrence rate compared to group A (recurrence rate: 11 of 23 patients [47.8%] vs five of five patients [100%], respectively; p=0.033).
This report is the first to validate the definition of BPRC. Group B had much worse outcomes, and whether group B BRPC can be categorized as BRPC together with group A is questionable. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 G704-SER000001589.2014.8.5.004 |
ISSN: | 1976-2283 2005-1212 2005-1212 |
DOI: | 10.5009/gnl13264 |