Effectiveness of Capsule Endoscopy Compared with Other Diagnostic Modalities in Patients with Small Bowel Crohn’s Disease: A Meta-Analysis

• Published in: Gut and liver Vol. 11; no. 1; pp. 62 - 72
• Main Authors: Choi, Miyoung, Lim, Sungwon, Choi, Myung-Gyu, Shim, Ki-Nam, Lee, Seon Heui
• Format: Journal Article
• Language: English
• Published: Korea (South) Editorial Office of Gut and Liver 01.01.2017; Gastroenterology Council for Gut and Liver; 거트앤리버 소화기연관학회협의회
• Subjects: Capsule Endoscopy; crohn disease; Crohn Disease - diagnosis; Crohn Disease - diagnostic imaging; Crohn Disease - pathology; diagnostic yield; Endoscopy, Digestive System; Humans; intestine; Intestine, Small - diagnostic imaging; Intestine, Small - pathology; Magnetic Resonance Imaging; meta-analysis; Original; small; Tomography, X-Ray Computed; 내과학; Crohn disease; Diagnostic yield; Intestine, small; Capsule endoscopy; Meta-analysis
• ISSN: 1976-2283; 2005-1212; 2005-1212
• DOI: 10.5009/gnl16015

As a result of the rapid development of medical diagnostic tools, physicians require concrete evidence to evaluate the effectiveness of the tools. We aimed to investigate the effectiveness and additional diagnostic benefits of capsule endoscopy (CE) in patients with small bowel Crohn's disease (CD). We performed a systematic search of databases, including MEDLINE, EMBASE, and the Cochrane Library, as well as eight domestic databases. Two reviewers independently screened all references. Diagnostic data from the studies were collected, and a meta-analysis was performed. Twenty-four studies were included. In cases of suspected CD, CE demonstrated a superior diagnostic yield compared with small bowel follow-through (SBFT) and enteroclysis (EC); however, there was no difference compared with computed tomography enterography or magnetic resonance enterography. In cases with established CD, CE demonstrated a higher diagnostic yield only compared with EC. In the detection of terminal ileum lesions, CE exhibited a significantly increased detection rate compared with ileoscopy. The findings of our meta-analysis indicate that CE is superior to SBFT and EC in the evaluation of suspected CD cases. CE is also a more effective diagnostic modality in patients with established CD compared with EC.