Cardiac and Vascular Consequences of Pre‐Hypertension in Youth

Hypertension is associated with increased left ventricular mass (LVM) and carotid intima‐media thickness (cIMT), which predict cardiovascular (CV) events in adults. Whether target organ damage is found in pre‐hypertensive youth is not known. The authors measured body mass index, blood pressure, fast...

Full description

Saved in:
Bibliographic Details
Published inThe journal of clinical hypertension (Greenwich, Conn.) Vol. 13; no. 5; pp. 332 - 342
Main Authors Urbina, Elaine M., Khoury, Philip R., McCoy, Connie, Daniels, Stephen R., Kimball, Thomas R., Dolan, Lawrence M.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.05.2011
Subjects
Online AccessGet full text
ISSN1524-6175
1751-7176
1751-7176
DOI10.1111/j.1751-7176.2011.00471.x

Cover

More Information
Summary:Hypertension is associated with increased left ventricular mass (LVM) and carotid intima‐media thickness (cIMT), which predict cardiovascular (CV) events in adults. Whether target organ damage is found in pre‐hypertensive youth is not known. The authors measured body mass index, blood pressure, fasting glucose, insulin, lipids and C‐reactive protein, LVM/height2.7 (LVM index), diastolic function, cIMT, carotid stiffness, augmentation index, brachial artery distensibility, and pulse wave velocity (PWV) in 723 patients aged 10 to 23 years (29% with type 2 diabetes mellitus). Patients were stratified by blood pressure level (normotensive: 531, pre‐hypertensive: 65, hypertensive: 127). Adiposity and CV risk factors worsened across blood pressure group. There was a graded increase in cIMT, arterial stiffness, and LVM index and decrease in diastolic function from normotension to pre‐hypertension to hypertension. In multivariable models adjusted for CV risk factors, status as pre‐hypertension or hypertension remained an independent determinant of target organ damage for LVM, diastolic function, internal cIMT, and carotid and arterial stiffness. Pre‐hypertension is associated with cardiovascular target organ damage in adolescents and young adults. J Clin Hypertens (Greenwich). 2011;13:332–342. ©2011 Wiley Periodicals, Inc.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1524-6175
1751-7176
1751-7176
DOI:10.1111/j.1751-7176.2011.00471.x