Lipid-based oral formulation in capsules to improve the delivery of poorly water-soluble drugs

• Published in: Frontiers in Drug Delivery Vol. 3; p. 1232012
• Main Authors: Mohite, Popat, Singh, Sudarshan, Pawar, Anil, Sangale, Adinath, Prajapati, Bhupendra G.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 24.08.2023
• Subjects: BCS-II; bioavailability; Drug Delivery; improved solubility; lipids; oral drug delivery; stability; lipids; bioavailability; improved solubility; BCS-II; oral drug delivery; stability
• ISSN: 2674-0850; 2674-0850
• DOI: 10.3389/fddev.2023.1232012

Poorly water-soluble drugs demonstrate significant challenge in pharmaceutical development, which is linked to their limited oral bioavailability and therapeutic efficacy. To overcome these limitations, lipid-based formulations have emerged as a promising approach to enhance the delivery of such drugs. Moreover, encapsulation within capsules to provide a convenient dosage form for oral administration. The encapsulation techniques are optimized to ensure uniform drug content and efficient encapsulation efficiency. Several investigations demonstrated that the lipid-based formulations in capsules significantly improved the solubility and dissolution rate of poorly water-soluble drugs compared to non-lipid formulations. Additionally, the encapsulation of lipid-based formulations protected the drug against degradation and improved its stability. Overall, incorporating lipid-based formulations in capsules represents a promising strategy for enhancing the delivery of poorly water-soluble drugs with improvement in solubility, dissolution, stability, and bioavailability, overcoming the challenges associated with these challenging drug molecules. The review focussed a brief on utilization of lipids in capsule form to improve therapeutic efficacy of poorly soluble, dissolution and bioavailability of drugs.