Clinical Significance of Measuring Myeloperoxidase, Thiobarbituric Acid Reactive Material and 7S Collagen in Plasma of Patients with Adult Respiratory Distress Syndrome
We measured myeloperoxidase (MPO), thiobarbituric acid reactive material (TBARM), and Type IV collagen 7S domain (7S collagen) in the plasma of 21 patients with acute lung injury (ALI). Sixteen healthy subjects served as a control group. There was no significant difference in MPO between the control...
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| Published in | Internal Medicine Vol. 33; no. 5; pp. 257 - 262 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Tokyo
The Japanese Society of Internal Medicine
1994
Japanese Society of Internal Medicine |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0918-2918 1349-7235 1349-7235 |
| DOI | 10.2169/internalmedicine.33.257 |
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| Abstract | We measured myeloperoxidase (MPO), thiobarbituric acid reactive material (TBARM), and Type IV collagen 7S domain (7S collagen) in the plasma of 21 patients with acute lung injury (ALI). Sixteen healthy subjects served as a control group. There was no significant difference in MPO between the control and ALI groups. The TBARM and 7S collagen concentrations in ALI (TBARM; 3.05±0.65 nMol/ml, 7S collagen 9.06±5.96 ng/ml: Mean±SD) were significantly higher than those in the control group (2.54±0.33 and 3.43±1.05, p<0.05). TBARM and 7S collagen levels of deceased ALI patients were higher than those of surviving ALI patients (p<0.05). There were significant correlations between the plasma levels of these two parameters and the lung injury scores. Our findings suggest that plasma TBARM and 7S collagen are useful markers for the assessment of the severity of ARDS. (Internal Medicine 33: 257-262, 1994) |
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| AbstractList | We measured myeloperoxidase (MPO), thiobarbituric acid reactive material (TBARM), and Type IV collagen 7S domain (7S collagen) in the plasma of 21 patients with acute lung injury (ALI). Sixteen healthy subjects served as a control group. There was no significant difference in MPO between the control and ALI groups. The TBARM and 7S collagen concentrations in ALI (TBARM; 3.05 +/- 0.65 nMol/ml, 7S collagen 9.06 +/- 5.96 ng/ml: Mean +/- SD) were significantly higher than those in the control group (2.54 +/- 0.33 and 3.43 +/- 1.05, p < 0.05). TBARM and 7S collagen levels of deceased ALI patients were higher than those of surviving ALI patients (p < 0.05). There were significant correlations between the plasma levels of these two parameters and the lung injury scores. Our findings suggest that plasma TBARM and 7S collagen are useful markers for the assessment of the severity of ARDS. We measured myeloperoxidase (MPO), thiobarbituric acid reactive material (TBARM), and Type IV collagen 7S domain (7S collagen) in the plasma of 21 patients with acute lung injury (ALI). Sixteen healthy subjects served as a control group. There was no significant difference in MPO between the control and ALI groups. The TBARM and 7S collagen concentrations in ALI (TBARM; 3.05 +/- 0.65 nMol/ml, 7S collagen 9.06 +/- 5.96 ng/ml: Mean +/- SD) were significantly higher than those in the control group (2.54 +/- 0.33 and 3.43 +/- 1.05, p < 0.05). TBARM and 7S collagen levels of deceased ALI patients were higher than those of surviving ALI patients (p < 0.05). There were significant correlations between the plasma levels of these two parameters and the lung injury scores. Our findings suggest that plasma TBARM and 7S collagen are useful markers for the assessment of the severity of ARDS.We measured myeloperoxidase (MPO), thiobarbituric acid reactive material (TBARM), and Type IV collagen 7S domain (7S collagen) in the plasma of 21 patients with acute lung injury (ALI). Sixteen healthy subjects served as a control group. There was no significant difference in MPO between the control and ALI groups. The TBARM and 7S collagen concentrations in ALI (TBARM; 3.05 +/- 0.65 nMol/ml, 7S collagen 9.06 +/- 5.96 ng/ml: Mean +/- SD) were significantly higher than those in the control group (2.54 +/- 0.33 and 3.43 +/- 1.05, p < 0.05). TBARM and 7S collagen levels of deceased ALI patients were higher than those of surviving ALI patients (p < 0.05). There were significant correlations between the plasma levels of these two parameters and the lung injury scores. Our findings suggest that plasma TBARM and 7S collagen are useful markers for the assessment of the severity of ARDS. We measured myeloperoxidase (MPO), thiobarbituric acid reactive material (TBARM), and Type IV collagen 7S domain (7S collagen) in the plasma of 21 patients with acute lung injury (ALI). Sixteen healthy subjects served as a control group. There was no significant difference in MPO between the control and ALI groups. The TBARM and 7S collagen concentrations in ALI (TBARM; 3.05±0.65 nMol/ml, 7S collagen 9.06±5.96 ng/ml: Mean±SD) were significantly higher than those in the control group (2.54±0.33 and 3.43±1.05, p<0.05). TBARM and 7S collagen levels of deceased ALI patients were higher than those of surviving ALI patients (p<0.05). There were significant correlations between the plasma levels of these two parameters and the lung injury scores. Our findings suggest that plasma TBARM and 7S collagen are useful markers for the assessment of the severity of ARDS. (Internal Medicine 33: 257-262, 1994) |
| Author | ISHIZAKA, Akitoshi URANO, Tetsuya WAKI, Yasuhiro TASAKA, Sadatomo FUJISHIMA, Seitaro KAWASHIRO, Takeo SAKAMAKI, Fumio TERASHIMA, Takeshi HASEGAWA, Naoki SAYAMA, Kohichi NAKAMURA, Hidetoshi KANAZAWA, Minoru |
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| References | 4) Fowler AA, Hyers TM, Fisher BJ, Bechard DE, Centor RM, Webster RO. The adult respiratory distress syndrome - Cell populations and soluble mediators in the air spaces of patients at high risk. Am Rev Respir Dis 136: 1225, 1987. 16) Hasegawa N, Ishizaka A, Kanazawa M, et al. Measurement of myeloperoxidase and thiobarbituric acid reactive material in plasma and bronchoalveolar lavage in E.coli induced acute lung injury. Jpn J Thoracic Dis 31: 924, 1993 (abstract in English). 17) Ishizaka A, Stephens KE, Tazelaar HD, Hall EW, O'Hanley P, Raffln TA. Pulmonary edema after Escherichia coli peritonitis correlates with thiobarbituric acid reactive materials in bronchoalveolar lavage fluid. Am Rev Respir Dis 137: 783, 1988. 8) Risteli J, Rohde H, Timple R. Sensitive radioimmunoassay for 7S collagen and laminin: Application to serum and tissue studies of basement membranes. Anal Biochem 113: 372, 1981. 1) Matthay MA. The adult respiratory distress syndrome - Definition and prognosis. Clin Chest Med 11: 575, 1990. 5) Rinaldo JE, Christman JW. Mechanisms and mediators of the adult respiratory distress syndrome. Clin Chest Med 11: 621, 1990. 9) Kondo Y, Taniguchi H, Taki F, Takagi K, Satake T. 7S collagen in bronchoalveolar lavage fluid of patients with adult respiratory distress syndrome. Chest 101: 1091, 1992. 12) Murray JF, Matthay MA, Luce JM, Flick MR. An expanded definition of the adult respiratory distress syndrome. Am Rev Respir Dis 138: 720, 1988. 7) Gutteridge JMC. Free-radical damage to lipids, amino acids, carbohydrates and nucleic acids determined by thiobarbituric acid reactivity. Eur J Biochem 14: 649, 1981. 6) Schultz J. Myeloperoxidase. The reticuloendothelial system. A Comprehensive Treatise Vol. 2. Biochemistry and Metabolism. Sbarra AJ, Strauss RR, Eds. Plenum Press, New York and London, 1980, p.231. 13) Henson PM, Zanlori B, Schwartzman NA, Hong SR. Intracellular control of human neutrophil secretion. J Immunol 121: 851, 1978. 14) Ohkawa H, Ohishi N, Yagi K. Reaction of linoleic acid hydroperoxide with thiobarbituric acid. J Lipid Res 19: 1053, 1978. 2) Weiland JE, Davis WB, Holter JF, Mohammed JR, Dorinsky PM, Gadek JE. Lung neutrophils in the adult respiratory distress syndrome - Clinical and pathophysiologic significance. Am Rev Respir Dis 133: 218, 1986. 3) Brigham KL, Meyrick B. Endotoxin and lung injury. Am Rev Respir Dis 133: 913, 1986. 15) HasegawaN, IshizakaA, Urano T, etal. Significance of myeloperoxidase activities in plasma and bronchoalveolar lavage fluid in endotoxininduced acute lung injury. In High Altitude Medicine, Ueda G, Reeves JT, Sekiguchi M, Eds. Shinshu University Press, Matsumoto, 1992, p. 365. 10) Tamura A, Matsubara O, Akagawa S, et al. Serum 7S collagen levels in diffuse interstitial lung disease - An index of the destruction of alveolar structure. Jpn J Thoracic Dis 30: 2089, 1992 (Abstract in English). 11) Montgomery AB, Stager MA, Carrico CJ, Hudson LD. Causes of mortality in patients with adult respiratory distress syndrome. Am Rev Respir Dis 132: 485, 1985. |
| References_xml | – reference: 17) Ishizaka A, Stephens KE, Tazelaar HD, Hall EW, O'Hanley P, Raffln TA. Pulmonary edema after Escherichia coli peritonitis correlates with thiobarbituric acid reactive materials in bronchoalveolar lavage fluid. Am Rev Respir Dis 137: 783, 1988. – reference: 15) HasegawaN, IshizakaA, Urano T, etal. Significance of myeloperoxidase activities in plasma and bronchoalveolar lavage fluid in endotoxininduced acute lung injury. In High Altitude Medicine, Ueda G, Reeves JT, Sekiguchi M, Eds. Shinshu University Press, Matsumoto, 1992, p. 365. – reference: 6) Schultz J. Myeloperoxidase. The reticuloendothelial system. A Comprehensive Treatise Vol. 2. Biochemistry and Metabolism. Sbarra AJ, Strauss RR, Eds. Plenum Press, New York and London, 1980, p.231. – reference: 3) Brigham KL, Meyrick B. Endotoxin and lung injury. Am Rev Respir Dis 133: 913, 1986. – reference: 5) Rinaldo JE, Christman JW. Mechanisms and mediators of the adult respiratory distress syndrome. Clin Chest Med 11: 621, 1990. – reference: 1) Matthay MA. The adult respiratory distress syndrome - Definition and prognosis. Clin Chest Med 11: 575, 1990. – reference: 13) Henson PM, Zanlori B, Schwartzman NA, Hong SR. Intracellular control of human neutrophil secretion. J Immunol 121: 851, 1978. – reference: 8) Risteli J, Rohde H, Timple R. Sensitive radioimmunoassay for 7S collagen and laminin: Application to serum and tissue studies of basement membranes. Anal Biochem 113: 372, 1981. – reference: 12) Murray JF, Matthay MA, Luce JM, Flick MR. An expanded definition of the adult respiratory distress syndrome. Am Rev Respir Dis 138: 720, 1988. – reference: 9) Kondo Y, Taniguchi H, Taki F, Takagi K, Satake T. 7S collagen in bronchoalveolar lavage fluid of patients with adult respiratory distress syndrome. Chest 101: 1091, 1992. – reference: 16) Hasegawa N, Ishizaka A, Kanazawa M, et al. Measurement of myeloperoxidase and thiobarbituric acid reactive material in plasma and bronchoalveolar lavage in E.coli induced acute lung injury. Jpn J Thoracic Dis 31: 924, 1993 (abstract in English). – reference: 4) Fowler AA, Hyers TM, Fisher BJ, Bechard DE, Centor RM, Webster RO. The adult respiratory distress syndrome - Cell populations and soluble mediators in the air spaces of patients at high risk. Am Rev Respir Dis 136: 1225, 1987. – reference: 2) Weiland JE, Davis WB, Holter JF, Mohammed JR, Dorinsky PM, Gadek JE. Lung neutrophils in the adult respiratory distress syndrome - Clinical and pathophysiologic significance. Am Rev Respir Dis 133: 218, 1986. – reference: 10) Tamura A, Matsubara O, Akagawa S, et al. Serum 7S collagen levels in diffuse interstitial lung disease - An index of the destruction of alveolar structure. Jpn J Thoracic Dis 30: 2089, 1992 (Abstract in English). – reference: 11) Montgomery AB, Stager MA, Carrico CJ, Hudson LD. Causes of mortality in patients with adult respiratory distress syndrome. Am Rev Respir Dis 132: 485, 1985. – reference: 14) Ohkawa H, Ohishi N, Yagi K. Reaction of linoleic acid hydroperoxide with thiobarbituric acid. J Lipid Res 19: 1053, 1978. – reference: 7) Gutteridge JMC. Free-radical damage to lipids, amino acids, carbohydrates and nucleic acids determined by thiobarbituric acid reactivity. Eur J Biochem 14: 649, 1981. |
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| SubjectTerms | acute lung injury Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers - blood Collagen - blood Female Humans lung injury score Male Medical sciences Middle Aged Peroxidase - blood plasma parameters Pneumology Prognosis Respiratory Distress Syndrome, Adult - blood Respiratory system : syndromes and miscellaneous diseases Thiobarbituric Acid Reactive Substances - metabolism |
| Title | Clinical Significance of Measuring Myeloperoxidase, Thiobarbituric Acid Reactive Material and 7S Collagen in Plasma of Patients with Adult Respiratory Distress Syndrome |
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