Clinical Significance of Measuring Myeloperoxidase, Thiobarbituric Acid Reactive Material and 7S Collagen in Plasma of Patients with Adult Respiratory Distress Syndrome

• Published in: Internal Medicine Vol. 33; no. 5; pp. 257 - 262
• Main Authors: KANAZAWA, Minoru, TERASHIMA, Takeshi, FUJISHIMA, Seitaro, HASEGAWA, Naoki, URANO, Tetsuya, WAKI, Yasuhiro, NAKAMURA, Hidetoshi, SAYAMA, Kohichi, KAWASHIRO, Takeo, TASAKA, Sadatomo, SAKAMAKI, Fumio, ISHIZAKA, Akitoshi
• Format: Journal Article
• Language: English
• Published: Tokyo The Japanese Society of Internal Medicine 1994; Japanese Society of Internal Medicine
• Subjects: acute lung injury; Adolescent; Adult; Aged; Aged, 80 and over; Biological and medical sciences; Biomarkers - blood; Collagen - blood; Female; Humans; lung injury score; Male; Medical sciences; Middle Aged; Peroxidase - blood; plasma parameters; Pneumology; Prognosis; Respiratory Distress Syndrome, Adult - blood; Respiratory system : syndromes and miscellaneous diseases; Thiobarbituric Acid Reactive Substances - metabolism; Human; Respiratory disease; Acute; Respiratory distress; Exploration; Diagnosis; Blood plasma
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.33.257

We measured myeloperoxidase (MPO), thiobarbituric acid reactive material (TBARM), and Type IV collagen 7S domain (7S collagen) in the plasma of 21 patients with acute lung injury (ALI). Sixteen healthy subjects served as a control group. There was no significant difference in MPO between the control and ALI groups. The TBARM and 7S collagen concentrations in ALI (TBARM; 3.05±0.65 nMol/ml, 7S collagen 9.06±5.96 ng/ml: Mean±SD) were significantly higher than those in the control group (2.54±0.33 and 3.43±1.05, p<0.05). TBARM and 7S collagen levels of deceased ALI patients were higher than those of surviving ALI patients (p<0.05). There were significant correlations between the plasma levels of these two parameters and the lung injury scores. Our findings suggest that plasma TBARM and 7S collagen are useful markers for the assessment of the severity of ARDS. (Internal Medicine 33: 257-262, 1994)