Strontium modified calcium phosphate cements - approaches towards targeted stimulation of bone turnover
Making use of the potential of calcium phosphates to host a variety of ions in their crystal lattice, ion substitution of calcium phosphate bone cements has become the subject of intense investigations in the last few years, since this approach allows one to stabilize a bone defect and to locally de...
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| Published in | Journal of materials chemistry. B, Materials for biology and medicine Vol. 3; no. 23; pp. 4626 - 464 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
England
21.06.2015
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| Subjects | |
| Online Access | Get full text |
| ISSN | 2050-750X 2050-7518 2050-7518 |
| DOI | 10.1039/c5tb00654f |
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| Summary: | Making use of the potential of calcium phosphates to host a variety of ions in their crystal lattice, ion substitution of calcium phosphate bone cements has become the subject of intense investigations in the last few years, since this approach allows one to stabilize a bone defect and to locally deliver therapeutic ions into a specific defect site at the same time. In this respect significant attention has been given to strontium ions (Sr
2+
) lately. Strontium possesses the unique potential to both stimulate new bone formation and inhibit cell-driven bone resorption and thus has been used successfully in systemic osteoporosis therapy. Strontium doping of calcium phosphate bone cements might allow making use of this dual effect to promote local bone defect healing. The goal of this review is to provide an overview of different routes that have been employed to obtain strontium-containing calcium phosphate bone cements and describe their material characteristics as well as their biological properties based on cell culture and animal studies.
Strontium modified calcium phosphate cements can target local bone turnover by stimulating osteoblast proliferation and differentiation (1) as well as bone mineralisation (2), reducing osteoclastogenesis (3) and resorption activity, increase osteoclast apoptosis (4) and affect osteoblast/osteoclast paracrine signalling (5). |
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| Bibliography: | Matthias Schumacher received his PhD at the Dresden University of Technology (TU Dresden, Germany) in 2014. Currently he is a post-doc researcher at the Centre for Translational Bone, Joint and Soft Tissue Research headed by Prof. Michael Gelinsky at the Medical Faculty of TU Dresden. He has a background in materials science and engineering and graduated from the University of Bayreuth, Germany in Materials Science. His research interests include the development of biomaterials, with focus on hard tissue reconstruction, calcium phosphates and tissue engineering as well as rapid prototyping of biomaterials. Michael Gelinsky is a Professor at the Medical Faculty of Dresden University of Technology (TU Dresden, Germany) and head of the Centre for Translational Bone, Joint and Soft Tissue Research. He obtained his PhD in Chemistry from Freiburg University (Germany), has headed a research group at the Max Bergmann Centre of Biomaterials (TU Dresden, Institute for Materials Science) and is a founder member of the Centre for Regenerative Therapies Dresden (CRTD). His multidisciplinary group is focused on novel therapeutic options for musculoskeletal diseases including biomaterial development, stem cell research and tissue engineering. His lab also has started to explore new technologies of additive manufacturing and biofabrication for medical applications. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 2050-750X 2050-7518 2050-7518 |
| DOI: | 10.1039/c5tb00654f |