Stem Cell Therapy in Treating Epilepsy

• Published in: Frontiers in neuroscience Vol. 16; p. 934507
• Main Authors: Chang, Bao-Luen, Chang, Kuo-Hsuan
• Format: Journal Article
• Language: English
• Published: Lausanne Frontiers Research Foundation 27.06.2022; Frontiers Media S.A
• Subjects: Animal models; Brain research; Cell culture; Cell differentiation; Cell therapy; Clinical trials; Convulsions & seizures; disease-modifying; Drug resistance; Embryo cells; Epilepsy; genetic engineering; graft; Inhibitory postsynaptic potentials; Mesenchyme; Mitochondria; Neural stem cells; Neurogenesis; Neurons; Neuroscience; Pluripotency; Reactive oxygen species; Remission (Medicine); seizure; Seizures; Stem cell transplantation; Stem cells
• ISSN: 1662-453X; 1662-4548; 1662-453X
• DOI: 10.3389/fnins.2022.934507

Epilepsy is a common disabling chronic neurological disorder characterized by an enduring propensity for the generation of seizures that result from abnormal hypersynchronous firing of neurons in the brain. Over 20–30% of epilepsy patients fail to achieve seizure control or soon become resistant to currently available therapies. Prolonged seizures or uncontrolled chronic seizures would give rise to neuronal damage or death, astrocyte activation, reactive oxygen species production, and mitochondrial dysfunction. Stem cell therapy is potentially a promising novel therapeutic strategy for epilepsy. The regenerative properties of stem cell-based treatment provide an attractive approach for long-term seizure control, particularly in drug-resistant epilepsy. Embryonic stem cells (ESCs), mesenchymal stem cells (MSCs), neural stem cells (NSCs), induced pluripotent stem cells (iPSCs), and adipose-derived regenerative cells (ADRCs) are capable of differentiating into specialized cell types has been applied for epilepsy treatment in preclinical animal research and clinical trials. In this review, we focused on the advances in stem cell therapy for epilepsies. The goals of stem cell transplantation, its mechanisms underlying graft effects, the types of grafts, and their therapeutic effects were discussed. The cell and animal models used for investigating stem cell technology in epilepsy treatment were summarized.