Prenatal Morphogenesis of Mammary Glands in Mouse and Rabbit

Our understanding of prenatal morphogenesis of mammary glands has recently greatly advanced. This review focuses on morphogenesis proper, as well as cellular processes and tissue interactions involved in the progression of the embryonic mammary gland through sequential morphogenic stages in both the...

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Bibliographic Details
Published inJournal of mammary gland biology and neoplasia Vol. 18; no. 2; pp. 93 - 104
Main Authors Propper, Alain Y., Howard, Beatrice A., Veltmaat, Jacqueline M.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.06.2013
Springer Nature B.V
Subjects
Animals
Cancer Research
Embryogenesis
Female
Mammary gland
Mammary Glands, Animal - embryology
Medicine
Medicine & Public Health
Morphogenesis
Morphogenesis - physiology
Oncology
Prenatal
Appendage
Embryo
Ectoderm
Mouse
Rabbit
Epidermis
Mammary gland
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ISSN1083-3021
1573-7039
1573-7039
DOI10.1007/s10911-013-9298-0

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Summary:Our understanding of prenatal morphogenesis of mammary glands has recently greatly advanced. This review focuses on morphogenesis proper, as well as cellular processes and tissue interactions involved in the progression of the embryonic mammary gland through sequential morphogenic stages in both the mouse and rabbit embryo. We provide a synthesis of both historical and more recent studies of embryonic mammary gland development, as well as arguments to revise old concepts about mechanisms of mammary line and rudiment formation. Finally, we highlight outstanding issues that remain to be addressed.
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ISSN:1083-3021
1573-7039
1573-7039
DOI:10.1007/s10911-013-9298-0