Effects of weight variability on cardiovascular risk factors; a study of nonsmoking Japanese male office workers

• Published in: International Journal of Obesity Vol. 24; no. 9; pp. 1226 - 1230
• Main Authors: Nakanishi, N, Nakamura, K, Suzuki, K, Tatara, K
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing 01.09.2000; Nature Publishing Group
• Subjects: Adult; Analysis. Health state; Biological and medical sciences; Blood pressure; Body mass index; Body Weight; Cardiovascular disease; Cardiovascular Diseases; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - etiology; Cholesterol; Diabetes; diastolic blood pressure; Environmental health; Epidemiology; etiology; General aspects; Glucose; Glycated Hemoglobin; Glycated Hemoglobin A; glycohemoglobin; Health risks; Hemoglobin; High density lipoprotein; high density lipoprotein cholesterol; Humans; Japan; Japan - epidemiology; Laboratories; Longitudinal Studies; Male; males; Medical sciences; Medicine; metabolic diseases; Middle Aged; Mortality; obesity; Obesity - epidemiology; Obesity - etiology; Occupations; Public health. Hygiene; Public health. Hygiene-occupational medicine; Regression Analysis; Risk Factors; Smoking; triacylglycerols; Uric acid; Japan; Human; Body mass index; Follow up study; Body weight; Variability; Risk factor; Adult; Cardiovascular disease; Male
• ISSN: 0307-0565; 1476-5497
• DOI: 10.1038/sj.ijo.0801389

OBJECTIVE: To determine the effects of weight variability on cardiovascular risk factors. DESIGN: Longitudinal study (followed from 1990 to 1998). SUBJECTS: Five-hundred and eighty nonsmoking Japanese male office workers aged 25-49 y. MEASUREMENTS: Baseline levels and slopes of seven selected cardiovascular risk factors (systolic and diastolic blood pressure, total and high-density lipoprotein cholesterol, triglyceride, uric acid and hemoglobin A1c) and body mass index (BMI) variables (baseline BMI, BMI-slope, the root mean square error (BMI-RMSE), and the BMI-slope x BMI-RMSE interaction). RESULTS: From the multiple regression analyses, the slopes of the six cardiovascular risk factors, except hemoglobin A1c, were most strongly related to the baseline level of each cardiovascular risk factor and BMI-slope. Neither BMI-RMSE nor the interaction of BMI-RMSE with BMI-slope was related to these cardiovascular risk factor slopes. As for hemoglobin A1c, BMI-slope and the interaction of BMI-RMSE with BMI-slope were not significantly related to hemoglobin A1c slope but baseline BMI and BMI-RMSE were. Furthermore, hemoglobin A1c slope values were significantly higher among those who cycled at >4.0 kg than among those who did not. CONCLUSION: The only cardiovascular risk factor associated with BMI variability was hemoglobin A1c. Weight variability had less or little impact on cardiovascular risk factors compared with BMI-slope and baseline BMI.