A carbon nanomaterial derived from a nanoscale covalent organic framework for photothermal therapy in the NIR-II biowindow

• Published in: Chemical communications (Cambridge, England) Vol. 56; no. 56; pp. 7793 - 7796
• Main Authors: Guan, Qun, Zhou, Le-Le, Zhou, Li-Na, Li, Mengdi, Qin, Guo-Xin, Li, Wen-Yan, Li, Yan-An, Dong, Yu-Bin
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 14.07.2020
• Subjects: Animals; Carbon; Carbon - chemistry; chemical compounds; Humans; in vivo studies; irradiation; MCF-7 Cells; Metal-Organic Frameworks - chemistry; Mice; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Nanomaterials; Nanoparticles; Nanostructures - chemistry; Photothermal conversion; Photothermal Therapy - methods; photothermotherapy; Porosity; porous media; Powder Diffraction; Pyrolysis; Spectroscopy, Near-Infrared - methods; Theranostic Nanomedicine; Xenograft Model Antitumor Assays
• ISSN: 1359-7345; 1364-548X; 1364-548X
• DOI: 10.1039/d0cc00861c

Herein, we report a microporous carbon nanomaterial that was generated from a nanoscale covalent organic framework precursor via a simple pyrolysis approach. The obtained carbon-based nanoparticles possessed a broad NIR absorption capacity and exhibited a high level of photothermal conversion ability ( η = 50.6%) in the NIR-II biowindow. Its excellent PTT antitumor efficiency was fully evidenced by in vitro and in vivo experiments under 1064 nm laser irradiation. A nanoscale carbon nanomaterial was synthesized through pyrolysis of its NCOF precursor, and the obtained carbon nanoparticles (CNPs) can be highly efficient NIR-II photothermal agents for antitumor treatment via PTT.