Randomized dose-ranging pilot trial of omega-3 fatty acids for postpartum depression

• Published in: Acta psychiatrica Scandinavica Vol. 113; no. 1; pp. 31 - 35
• Main Authors: Freeman, M. P., Hibbeln, J. R., Wisner, K. L., Brumbach, B. H., Watchman, M., Gelenberg, A. J.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Munksgaard International Publishers 01.01.2006; Blackwell
• Subjects: Adult; Adult and adolescent clinical studies; Biological and medical sciences; Depression; Depression, Postpartum - diagnosis; Depression, Postpartum - drug therapy; Depression, Postpartum - psychology; Diagnostic and Statistical Manual of Mental Disorders; Dose-Response Relationship, Drug; Drug Administration Schedule; Fatty Acids, Omega-3 - administration & dosage; Fatty Acids, Omega-3 - therapeutic use; Female; Humans; Medical sciences; Mood disorders; Mothers - psychology; omega-3 fatty acids; postpartum period; Pregnancy; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome; Mood disorder; Human; postpartum period; Lipids; Depression; omega-3 fatty acids; Puerperium; Fatty acids
• ISSN: 0001-690X; 1600-0447
• DOI: 10.1111/j.1600-0447.2005.00660.x

Objective:  Postpartum depression (PPD) affects 10–15% of mothers. Omega‐3 fatty acids are an intriguing potential treatment for PPD. Method:  The efficacy of omega‐3 fatty acids for PPD was assessed in an 8‐week dose‐ranging trial. Subjects were randomized to 0.5 g/day (n = 6), 1.4 g/day (n = 3), or 2.8 g/day (n = 7). Results:  Across groups, pretreatment Edinburgh Postnatal Depression Scale (EPDS) and Hamilton Rating Scale for Depression (HRSD) mean scores were 18.1 and 19.1 respectively; post‐treatment mean scores were 9.3 and 10.0. Percent decreases on the EPDS and HRSD were 51.5% and 48.8%, respectively; changes from baseline were significant within each group and when combining groups. Groups did not significantly differ in pre‐ or post‐test scores, or change in scores. The treatment was well tolerated. Conclusion:  This study was limited by small sample size and lack of placebo group. However, these results support further study of omega‐3 fatty acids as a treatment for PPD.