Anti-IgLON5 Disease – The Current State of Knowledge and Further Perspectives
Anti-IgLON5 disease is a relatively new neurological entity with the first cases reported in 2014. So far, less than 70 articles on this topic have been published. Due to its unspecific symptomatology, diverse progression, novelty and ambiguous character, it remains a difficulty for both clinical pr...
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| Published in | Frontiers in immunology Vol. 13; p. 852215 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
Frontiers Media S.A
01.03.2022
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1664-3224 1664-3224 |
| DOI | 10.3389/fimmu.2022.852215 |
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| Abstract | Anti-IgLON5 disease is a relatively new neurological entity with the first cases reported in 2014. So far, less than 70 articles on this topic have been published. Due to its unspecific symptomatology, diverse progression, novelty and ambiguous character, it remains a difficulty for both clinical practitioners and scientists. The aim of this review is to summarize the current knowledge concerning anti-IgLON5 disease; mechanisms underlying its cause, symptomatology, clinical progression, differential diagnosis and treatment, which could be helpful in clinical practice and future research. |
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| AbstractList | Anti-IgLON5 disease is a relatively new neurological entity with the first cases reported in 2014. So far, less than 70 articles on this topic have been published. Due to its unspecific symptomatology, diverse progression, novelty and ambiguous character, it remains a difficulty for both clinical practitioners and scientists. The aim of this review is to summarize the current knowledge concerning anti-IgLON5 disease; mechanisms underlying its cause, symptomatology, clinical progression, differential diagnosis and treatment, which could be helpful in clinical practice and future research.Anti-IgLON5 disease is a relatively new neurological entity with the first cases reported in 2014. So far, less than 70 articles on this topic have been published. Due to its unspecific symptomatology, diverse progression, novelty and ambiguous character, it remains a difficulty for both clinical practitioners and scientists. The aim of this review is to summarize the current knowledge concerning anti-IgLON5 disease; mechanisms underlying its cause, symptomatology, clinical progression, differential diagnosis and treatment, which could be helpful in clinical practice and future research. Anti-IgLON5 disease is a relatively new neurological entity with the first cases reported in 2014. So far, less than 70 articles on this topic have been published. Due to its unspecific symptomatology, diverse progression, novelty and ambiguous character, it remains a difficulty for both clinical practitioners and scientists. The aim of this review is to summarize the current knowledge concerning anti-IgLON5 disease; mechanisms underlying its cause, symptomatology, clinical progression, differential diagnosis and treatment, which could be helpful in clinical practice and future research. |
| Author | Przewodowska, Dominika Kowalska, Agata Alster, Piotr Marzec, Weronika Koziorowski, Dariusz Madetko, Natalia |
| AuthorAffiliation | 1 Department of Neurology, Medical University of Warsaw , Warsaw , Poland 2 Students’ Scientific Circle of the Department of Neurology, Medical University of Warsaw , Warsaw , Poland |
| AuthorAffiliation_xml | – name: 2 Students’ Scientific Circle of the Department of Neurology, Medical University of Warsaw , Warsaw , Poland – name: 1 Department of Neurology, Medical University of Warsaw , Warsaw , Poland |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35300333$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/S1474-4422(14)70051-1 10.1111/ene.14634 10.1097/MD.0000000000024384 10.1053/j.gastro.2007.04.070 10.29245/2572.942X/2020/3.1269 10.1212/NXI.0000000000000577 10.3389/fnins.2017.00038 10.1093/sleep/zsz133 10.1212/NXI.0000000000000302 10.1212/NXI.0000000000000385 10.3389/fpsyt.2020.00576 10.1111/ane.13207 10.1186/s12883-021-02145-4 10.3389/fneur.2021.632497 10.1001/jamaneurol.2019.3638 10.1016/j.jns.2019.07.010 10.1212/WNL.0000000000012639 10.1016/j.dld.2005.11.013 10.1212/WNL.0000000000003887 10.1212/WNL.0b013e3182a9585f 10.1007/s00415-020-10386-5 10.1212/NXI.0000000000001116 10.1016/s1388-2457(02)00022-6 10.3390/cells10030656 10.1111/j.1440-1681.2004.04002.x 10.1212/NXI.0000000000000962 10.1212/NXI.0000000000000605 10.1111/ene.14308 10.1111/cns.13038 10.1038/s41386-019-0463-z 10.3233/JND-170259 10.1007/s11910-018-0848-0 10.1016/j.smrv.2021.101515 10.1007/s00415-019-09221-3 10.1016/S0140-6736(15)60445-7 10.1002/cbf.1600 10.3389/fneur.2019.01056 10.1212/NXI.0000000000001009 10.1002/lary.28911 10.1002/mds.26987 10.1111/nyas.12553 10.1097/WCO.0000000000000677 10.1016/S1474-4422(09)70324-2 10.1212/NXI.0000000000000651 10.3390/cells10040837 10.1016/j.jneuroim.2016.09.012 10.1177/1176934318775081 10.1186/s13223-021-00557-y 10.3389/fimmu.2021.753856 10.1212/NXI.0000000000000136 10.1212/WNL.0000000000005679 10.1007/s00401-016-1591-8 10.1186/s12974-016-0689-1 10.1002/mdc3.13016 10.1002/mds.26608 10.1007/s00415-020-09924-y 10.1016/j.cca.2021.07.008 10.3389/fnmol.2018.00008 10.1111/ene.15117 10.1158/1078-0432.CCR-04-2388 10.1007/s11940-018-0515-4 10.3390/cells10020417 |
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| Copyright | Copyright © 2022 Madetko, Marzec, Kowalska, Przewodowska, Alster and Koziorowski. Copyright © 2022 Madetko, Marzec, Kowalska, Przewodowska, Alster and Koziorowski 2022 Madetko, Marzec, Kowalska, Przewodowska, Alster and Koziorowski |
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| Keywords | neurodegeneration IgLON5 disease neuroinflammation IgLON5 antibodies autoimmune disease |
| Language | English |
| License | Copyright © 2022 Madetko, Marzec, Kowalska, Przewodowska, Alster and Koziorowski. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Reviewed by: Linda Beenet, University of California, United States; Masharip Atadzhanov, University of Zambia, Zambia Edited by: Alessandro Granito, University of Bologna, Italy This article was submitted to Autoimmune and Autoinflammatory Disorders, a section of the journal Frontiers in Immunology |
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| References | Heidbreder (B13) 2018; 20 Brunetti (B60) 2019; 6 B23 Pi (B46) 2021; 100 Ye (B24) 2021; 521 Antelmi (B37) 2021; 60 Lim (B25) 2021; 10 Denton (B4) 2004; 31 Chen (B56) 2020; 77 El Shazly (B44) 2021; 12 Volta (B53) 2006; 38 Nissen (B28) 2019; 10 Hansen (B29) 2020; 11 Hashimoto (B10) 2009; 27 Peeters (B31) 2020; 7 González-Ávila (B19) 2021; 28 Rauf (B21) 2020 Sabater (B7) 2014; 13 Höglinger (B20) 2017; 32 Erro (B30) 2019; 7 Schröder (B41) 2016; 4 Grüter (B48) 2020; 267 da Silva (B5) 2020; 5 Kubick (B8) 2018; 14 Wang (B14) 2021; 21 Leypoldt (B26) 2015; 1338 Gaig (B35) 2019; 32 Ryding (B17) 2021; 10 Ntougkos (B22) 2005; 11 Gaig (B38) 2019; 42 Dalakas (B61) 2021; 9 Simabukuro (B49) 2015; 2 Vanaveski (B2) 2017; 11 Höftberger (B15) 2013; 81 Logmin (B50) 2019; 266 Lancaster (B16) 2010; 9 Morales-Briceno (B51) 2018; 90 Werner (B6) 2021; 8 Shambrook (B59) 2021; 8 Sabater (B27) 2016; 13 Cabezudo-García (B58) 2020; 141 Granito (B54) 2021; 17 Ni (B55) 2021; 29 Haitao (B57) 2016; 300 Högl (B62) 2015; 385 Hongo (B18) 2019 Macher (B43) 2021; 12 Tao (B36) 2018; 24 Chen (B42) 2021; 131 Gaig (B1) 2017; 88 Gaig (B39) 2018; 18 Gelpi (B11) 2016; 132 Honorat (B3) 2017; 4 Wenninger (B12) 2017; 4 Cervio (B52) 2007; 133 Karis (B9) 2018; 11 Gaig (B45) 2019; 6 Montagna (B47) 2002; 113 Brüggemann (B32) 2016; 31 Gaig (B33) 2021; 97 Iranzo (B34) 2020; 45 Helmchen (B40) 2021; 268 Koziorowski (B63) 2021; 10 |
| References_xml | – volume: 13 year: 2014 ident: B7 article-title: A Novel non-Rapid-Eye Movement and Rapid-Eye-Movement Parasomnia With Sleep Breathing Disorder Associated With Antibodies to IgLON5: A Case Series, Characterisation of the Antigen, and Post-Mortem Study publication-title: Lancet Neurol doi: 10.1016/S1474-4422(14)70051-1 – volume: 28 year: 2021 ident: B19 article-title: Altered Ioflupane Single-Photon Emission Computed Tomography in Anti-IgLON5 Disease: A New Case Mimicking Probable Progressive Supranuclear Palsy and Review of the Literature publication-title: Eur J Neurol doi: 10.1111/ene.14634 – volume: 100 start-page: e24384 year: 2021 ident: B46 article-title: Anti-IgLON5 Disease With Distinctive Brain MRI Findings Responding to Immunotherapy: A Case Report publication-title: Med (Baltimore) doi: 10.1097/MD.0000000000024384 – volume: 133 start-page: 195 year: 2007 ident: B52 article-title: Sera of Patients With Celiac Disease and Neurologic Disorders Evoke a Mitochondrial-Dependent Apoptosis In Vitro publication-title: Gastroenterology doi: 10.1053/j.gastro.2007.04.070 – volume: 5 year: 2020 ident: B5 article-title: Anti-Iglon5 Syndrome: What We Know So Far? A Non-Systematic Review publication-title: J Neurol Neuromed doi: 10.29245/2572.942X/2020/3.1269 – volume: 6 start-page: e577 year: 2019 ident: B60 article-title: Immunotherapy Improves Sleep and Cognitive Impairment in Anti-IgLON5 Encephalopathy publication-title: Neurol Neuroimmunol Neuroinflamm doi: 10.1212/NXI.0000000000000577 – volume: 11 year: 2017 ident: B2 article-title: Promoter-Specific Expression and Genomic Structure of IgLON Family Genes in Mouse publication-title: Front Neurosci doi: 10.3389/fnins.2017.00038 – volume: 42 year: 2019 ident: B38 article-title: Characterization of the Sleep Disorder of Anti-IgLON5 Disease publication-title: Sleep doi: 10.1093/sleep/zsz133 – volume: 4 start-page: e302 year: 2016 ident: B41 article-title: Isolated Dysphagia as Initial Sign of Anti-IgLON5 Syndrome publication-title: Neurol Neuroimmunol Neuroinflamm doi: 10.1212/NXI.0000000000000302 – volume: 4 start-page: e385 year: 2017 ident: B3 article-title: IgLON5 Antibody: Neurological Accompaniments and Outcomes in 20 Patients publication-title: Neurol Neuroimmunol Neuroinflamm doi: 10.1212/NXI.0000000000000385 – volume: 11 year: 2020 ident: B29 article-title: Figural Memory Impairment in Conjunction With Neuropsychiatric Symptoms in IgLON5 Antibody-Associated Autoimmune Encephalitis publication-title: Front Psychiatry doi: 10.3389/fpsyt.2020.00576 – volume: 141 year: 2020 ident: B58 article-title: Response to Immunotherapy in Anti-IgLON5 Disease: A Systematic Review publication-title: Acta Neurol Scand doi: 10.1111/ane.13207 – volume: 21 start-page: 120 year: 2021 ident: B14 article-title: Improvement in Mild Anti-IgLON5 Encephalopathy Without Immunotherapy: A Case Report publication-title: BMC Neurol doi: 10.1186/s12883-021-02145-4 – volume: 12 year: 2021 ident: B44 article-title: Case Report: Neuropsychological Findings in IgLON5 Antibody Disorder publication-title: Front Neurol doi: 10.3389/fneur.2021.632497 – volume: 77 year: 2020 ident: B56 article-title: Distinctive Magnetic Resonance Imaging Findings in IgLON5 Antibody Disease publication-title: JAMA Neurol doi: 10.1001/jamaneurol.2019.3638 – year: 2019 ident: B18 article-title: An Autopsy Case of MM2-Thalamic Subtype of Sporadic Creutzfeldt-Jakob Disease With Lewy Bodies Presenting as a Sleep Disorder Mimicking Anti-IgLON5 Disease publication-title: J Neurol Sci doi: 10.1016/j.jns.2019.07.010 – volume: 97 year: 2021 ident: B33 article-title: Frequency and Characterization of Movement Disorders in Anti-IgLON5 Disease publication-title: Neurology doi: 10.1212/WNL.0000000000012639 – volume: 38 year: 2006 ident: B53 article-title: Anti-Ganglioside Antibodies in Coeliac Disease With Neurological Disorders publication-title: Digestive Liver Dis doi: 10.1016/j.dld.2005.11.013 – volume: 88 year: 2017 ident: B1 article-title: Clinical Manifestations of the Anti-IgLON5 Disease publication-title: Neurology doi: 10.1212/WNL.0000000000003887 – volume: 81 year: 2013 ident: B15 article-title: Encephalitis and GABAB Receptor Antibodies: Novel Findings in a New Case Series of 20 Patients publication-title: Neurology doi: 10.1212/WNL.0b013e3182a9585f – volume: 268 year: 2021 ident: B40 article-title: Bilateral Vestibulopathy in Anti-IgLON5 Disease publication-title: J Neurol doi: 10.1007/s00415-020-10386-5 – volume: 9 start-page: e1116 year: 2021 ident: B61 article-title: IgG4-Mediated Neurologic Autoimmunities: Understanding the Pathogenicity of IgG4, Ineffectiveness of IVIg, and Long-Lasting Benefits of Anti-B Cell Therapies publication-title: Neurol Neuroimmunol Neuroinflamm doi: 10.1212/NXI.0000000000001116 – volume: 113 year: 2002 ident: B47 article-title: Agrypnia Excitata: A Generalized Overactivity Syndrome and a Useful Concept in the Neurophysiopathology of Sleep publication-title: Clin Neurophysiol doi: 10.1016/s1388-2457(02)00022-6 – volume: 10 year: 2021 ident: B63 article-title: Mechanisms of Neurodegeneration in Various Forms of Parkinsonism—Similarities and Differences publication-title: Cells doi: 10.3390/cells10030656 – volume: 31 year: 2004 ident: B4 article-title: Differential Neural Control of Glomerular Ultrafiltration publication-title: Clin Exp Pharmacol Physiol doi: 10.1111/j.1440-1681.2004.04002.x – volume: 8 start-page: e962 year: 2021 ident: B6 article-title: Anti-IgLON5 Disease: A New Bulbar-Onset Motor Neuron Mimic Syndrome publication-title: Neurol Neuroimmunol Neuroinflamm doi: 10.1212/NXI.0000000000000962 – volume: 6 start-page: e605 year: 2019 ident: B45 article-title: HLA and Microtubule-Associated Protein Tau H1 Haplotype Associations in Anti-IgLON5 Disease publication-title: Neurol Neuroimmunol Neuroinflamm doi: 10.1212/NXI.0000000000000605 – year: 2020 ident: B21 article-title: Anti-IGLON5-Syndrom Presenting Fasciculations and Oculomotor Palsy Associated With Renal Neoplasia publication-title: Eur J Of Neurol. SUPnan doi: 10.1111/ene.14308 – volume: 24 year: 2018 ident: B36 article-title: Motor Neuron Disease-Like Phenotype Associated With Anti-IgLON5 Disease publication-title: CNS Neurosci Ther doi: 10.1111/cns.13038 – volume: 45 year: 2020 ident: B34 article-title: Sleep and Neurological Autoimmune Diseases publication-title: Neuropsychopharmacol doi: 10.1038/s41386-019-0463-z – volume: 4 year: 2017 ident: B12 article-title: Expanding the Clinical Spectrum of IgLON5-Syndrome publication-title: J Neuromuscul Dis doi: 10.3233/JND-170259 – volume: 18 start-page: 41 year: 2018 ident: B39 article-title: The Sleep Disorder in Anti-Lglon5 Disease publication-title: Curr Neurol Neurosci Rep doi: 10.1007/s11910-018-0848-0 – volume: 60 year: 2021 ident: B37 article-title: REM Sleep Behavior Disorder: Mimics and Variants publication-title: Sleep Med Rev doi: 10.1016/j.smrv.2021.101515 – volume: 266 year: 2019 ident: B50 article-title: Intravenous Immunoglobulins as First-Line Therapy for IgLON5 Encephalopathy publication-title: J Neurol doi: 10.1007/s00415-019-09221-3 – volume: 385 start-page: 1590 year: 2015 ident: B62 article-title: IgLON5 Autoimmunity and Abnormal Behaviours During Sleep publication-title: Lancet doi: 10.1016/S0140-6736(15)60445-7 – volume: 27 year: 2009 ident: B10 article-title: IgLON Cell Adhesion Molecules Regulate Synaptogenesis in Hippocampal Neurons publication-title: Cell Biochem Funct doi: 10.1002/cbf.1600 – volume: 10 year: 2019 ident: B28 article-title: Anti-IgLON5 Disease: A Case With 11-Year Clinical Course and Review of the Literature publication-title: Front Neurol doi: 10.3389/fneur.2019.01056 – volume: 8 start-page: e1009 year: 2021 ident: B59 article-title: Delayed Benefit From Aggressive Immunotherapy in Waxing and Waning Anti-IgLON5 Disease publication-title: Neurol Neuroimmunol Neuroinflamm doi: 10.1212/NXI.0000000000001009 – volume: 131 year: 2021 ident: B42 article-title: A Novel Presentation of the Acute Airway: Anti-IgLON5 Disease publication-title: Laryngoscope doi: 10.1002/lary.28911 – volume: 32 year: 2017 ident: B20 article-title: Movement Disorder Society-Endorsed PSP Study Group. Clinical Diagnosis of Progressive Supranuclear Palsy: The Movement Disorder Society Criteria publication-title: Mov Disord doi: 10.1002/mds.26987 – ident: B23 – volume: 1338 start-page: 94 year: 2015 ident: B26 article-title: Autoimmune Encephalopathies publication-title: Ann N Y Acad Sci doi: 10.1111/nyas.12553 – volume: 32 year: 2019 ident: B35 article-title: Neurological Profiles Beyond the Sleep Disorder in Patients With Anti-IgLON5 Disease publication-title: Curr Opin Neurol doi: 10.1097/WCO.0000000000000677 – volume: 9 start-page: 67 year: 2010 ident: B16 article-title: Antibodies to the GABA(B) Receptor in Limbic Encephalitis With Seizures: Case Series and Characterisation of the Antigen publication-title: Lancet Neurol doi: 10.1016/S1474-4422(09)70324-2 – volume: 7 start-page: e651 year: 2019 ident: B30 article-title: Anti-IGLON5 Disease: A New Case Without Neuropathologic Evidence of Brainstem Tauopathy publication-title: Neurol Neuroimmunol Neuroinflamm doi: 10.1212/NXI.0000000000000651 – volume: 10 start-page: 837 year: 2021 ident: B17 article-title: Neurodegeneration Induced by Anti-IgLON5 Antibodies Studied in Induced Pluripotent Stem Cell-Derived Human Neurons publication-title: Cells doi: 10.3390/cells10040837 – volume: 300 start-page: 9 year: 2016 ident: B57 article-title: Chorea and Parkinsonism Associated With Autoantibodies to IgLON5 and Responsive to Immunotherapy publication-title: J Neuroimmunol doi: 10.1016/j.jneuroim.2016.09.012 – volume: 14 year: 2018 ident: B8 article-title: Molecular Evolution and Functional Divergence of the IgLON Family publication-title: Evol Bioinform Online doi: 10.1177/1176934318775081 – volume: 17 start-page: 53 year: 2021 ident: B54 article-title: Anti-Ganglioside Antibodies and Celiac Disease publication-title: Allergy Asthma Clin Immunol doi: 10.1186/s13223-021-00557-y – volume: 12 year: 2021 ident: B43 article-title: Ocular Motor Abnormalities in Anti-IgLON5 Disease publication-title: Front Immunol doi: 10.3389/fimmu.2021.753856 – volume: 2 start-page: e136 year: 2015 ident: B49 article-title: Sleep Disorder, Chorea, and Dementia Associated With IgLON5 Antibodies publication-title: Neurol Neuroimmunol Neuroinflamm doi: 10.1212/NXI.0000000000000136 – volume: 90 year: 2018 ident: B51 article-title: IgLON5-Mediated Neurodegeneration Is a Differential Diagnosis of CNS Whipple Disease publication-title: Neurology doi: 10.1212/WNL.0000000000005679 – volume: 132 year: 2016 ident: B11 article-title: Neuropathological Criteria of Anti-IgLON5-Related Tauopathy publication-title: Acta Neuropathol doi: 10.1007/s00401-016-1591-8 – volume: 13 start-page: 226 year: 2016 ident: B27 article-title: Cellular Investigations With Human Antibodies Associated With the Anti-IgLON5 Syndrome publication-title: J Neuroinflammation doi: 10.1186/s12974-016-0689-1 – volume: 7 year: 2020 ident: B31 article-title: Unusual Head Movements in Anti-IgLON5 Disease publication-title: Mov Disord Clin Pract doi: 10.1002/mdc3.13016 – volume: 31 year: 2016 ident: B32 article-title: Dystonia, Lower Limb Stiffness, and Upward Gaze Palsy in a Patient With IgLON5 Antibodies publication-title: Mov Disord doi: 10.1002/mds.26608 – volume: 267 year: 2020 ident: B48 article-title: Early Immunotherapy Is Highly Effective in IgG1/IgG4 Positive IgLON5 Disease publication-title: J Neurol doi: 10.1007/s00415-020-09924-y – volume: 521 year: 2021 ident: B24 article-title: Anti-IgLON5 Disease in a Pediatric Patient With Langerhans Cell Histiocytosis publication-title: Clin Chim Acta doi: 10.1016/j.cca.2021.07.008 – volume: 11 year: 2018 ident: B9 article-title: Altered Expression Profile of IgLON Family of Neural Cell Adhesion Molecules in the Dorsolateral Prefrontal Cortex of Schizophrenic Patients publication-title: Front Mol Neurosci doi: 10.3389/fnmol.2018.00008 – volume: 29 year: 2021 ident: B55 article-title: Expanding the Clinical Spectrum of Anti-IgLON5 Disease: A Multicenter Retrospective Study publication-title: Eur J Neurol doi: 10.1111/ene.15117 – volume: 11 year: 2005 ident: B22 article-title: The IgLON Family in Epithelial Ovarian Cancer: Expression Profiles and Clinicopathologic Correlates publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-04-2388 – volume: 20 start-page: 29 year: 2018 ident: B13 article-title: Anti-IgLON 5 Disease publication-title: Curr Treat Options Neurol doi: 10.1007/s11940-018-0515-4 – volume: 10 year: 2021 ident: B25 article-title: IgLON5 Regulates the Adhesion and Differentiation of Myoblasts publication-title: Cells doi: 10.3390/cells10020417 |
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| SubjectTerms | autoimmune disease Cell Adhesion Molecules, Neuronal Encephalitis Hashimoto Disease Humans IgLON5 antibodies IgLON5 disease Immunology neurodegeneration neuroinflammation |
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| Title | Anti-IgLON5 Disease – The Current State of Knowledge and Further Perspectives |
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