Anti-IgLON5 Disease – The Current State of Knowledge and Further Perspectives

Anti-IgLON5 disease is a relatively new neurological entity with the first cases reported in 2014. So far, less than 70 articles on this topic have been published. Due to its unspecific symptomatology, diverse progression, novelty and ambiguous character, it remains a difficulty for both clinical pr...

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Published inFrontiers in immunology Vol. 13; p. 852215
Main Authors Madetko, Natalia, Marzec, Weronika, Kowalska, Agata, Przewodowska, Dominika, Alster, Piotr, Koziorowski, Dariusz
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 01.03.2022
Subjects
autoimmune disease
Cell Adhesion Molecules, Neuronal
Encephalitis
Hashimoto Disease
Humans
IgLON5 antibodies
IgLON5 disease
Immunology
neurodegeneration
neuroinflammation
neurodegeneration
IgLON5 disease
neuroinflammation
IgLON5 antibodies
autoimmune disease
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ISSN1664-3224
1664-3224
DOI10.3389/fimmu.2022.852215

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Summary:Anti-IgLON5 disease is a relatively new neurological entity with the first cases reported in 2014. So far, less than 70 articles on this topic have been published. Due to its unspecific symptomatology, diverse progression, novelty and ambiguous character, it remains a difficulty for both clinical practitioners and scientists. The aim of this review is to summarize the current knowledge concerning anti-IgLON5 disease; mechanisms underlying its cause, symptomatology, clinical progression, differential diagnosis and treatment, which could be helpful in clinical practice and future research.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Review-3
content type line 23
Reviewed by: Linda Beenet, University of California, United States; Masharip Atadzhanov, University of Zambia, Zambia
Edited by: Alessandro Granito, University of Bologna, Italy
This article was submitted to Autoimmune and Autoinflammatory Disorders, a section of the journal Frontiers in Immunology
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.852215