Emergence of plasmid-mediated colistin resistance (MCR-1) among Escherichia coli isolated from South African patients

The polymyxin antibiotic colistin is an antibiotic of last resort for the treatment of extensively drug-resistant Gram-negative bacteria, including carbapenemase-producing Enterobacteriaceae. The State of the World's Antibiotics report in 2015 highlighted South Africa (SA)'s increasing inc...

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Published inSouth African medical journal Vol. 106; no. 5; p. 35
Main Authors Coetzee, Jennifer, Corcoran, Craig, Prentice, Elizabeth, Moodley, Mischka, Mendelson, Marc, Poirel, Laurent, Nordmann, Patrice, Brink, Adrian John
Format Journal Article
LanguageEnglish
Published South Africa Health & Medical Publishing Group 01.05.2016
Subjects
Adult
Aged
Animals
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Bacterial pneumonia
Care and treatment
Colistin - pharmacology
Drug resistance in microorganisms
Drug Resistance, Bacterial
Escherichia coli - drug effects
Escherichia coli - genetics
Escherichia coli Proteins - analysis
Female
Humans
Male
Meat - microbiology
Middle Aged
Plasmids
Pneumonia
Public Health
South Africa
South Africa
Online AccessGet full text
ISSN0256-9574
DOI10.7196/SAMJ.2016.v106i5.10710

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Abstract The polymyxin antibiotic colistin is an antibiotic of last resort for the treatment of extensively drug-resistant Gram-negative bacteria, including carbapenemase-producing Enterobacteriaceae. The State of the World's Antibiotics report in 2015 highlighted South Africa (SA)'s increasing incidence of these 'superbugs' (3.2% of Klebsiella pneumoniae reported from SA were carbapenemase producers), and in doing so, underscored SA's increasing reliance on colistin as a last line of defence. Colistin resistance effectively renders such increasingly common infections untreatable.
AbstractList The polymyxin antibiotic colistin is an antibiotic of last resort for the treatment of extensively drug-resistant Gram- negative bacteria, including carbapenemase-producing Enterobacteriaceae. The State of the World's Antibiotics report in 2015 highlighted South Africa (SA)'s increasing incidence of these 'superbugs' (3.2% of Klebsiella pneumoniae reported from SA were carbapenemase producers), and in doing so, underscored SA's increasing reliance on colistin as a last line of defence. Colistin resistance effectively renders such increasingly common infections untreatable. S Afr Med J 2016; 106(5):449-450. DOI: 10.7196/SAMJ.2016.v106i5.10710
The polymyxin antibiotic colistin is an antibiotic of last resort for the treatment of extensively drug-resistant Gram-negative bacteria, including carbapenemase-producing Enterobacteriaceae. The State of the World's Antibiotics report in 2015 highlighted South Africa (SA)'s increasing incidence of these 'superbugs' (3.2% of Klebsiella pneumoniae reported from SA were carbapenemase producers), and in doing so, underscored SA's increasing reliance on colistin as a last line of defence. Colistin resistance effectively renders such increasingly common infections untreatable.
The polymyxin antibiotic colistin is an antibiotic of last resort for the treatment of extensively drug-resistant Gram-negative bacteria, including carbapenemase-producing Enterobacteriaceae. The State of the World's Antibiotics report in 2015 highlighted South Africa (SA)'s increasing incidence of these 'superbugs' (3.2% of Klebsiella pneumoniae reported from SA were carbapenemase producers), and in doing so, underscored SA's increasing reliance on colistin as a last line of defence. Colistin resistance effectively renders such increasingly common infections untreatable.The polymyxin antibiotic colistin is an antibiotic of last resort for the treatment of extensively drug-resistant Gram-negative bacteria, including carbapenemase-producing Enterobacteriaceae. The State of the World's Antibiotics report in 2015 highlighted South Africa (SA)'s increasing incidence of these 'superbugs' (3.2% of Klebsiella pneumoniae reported from SA were carbapenemase producers), and in doing so, underscored SA's increasing reliance on colistin as a last line of defence. Colistin resistance effectively renders such increasingly common infections untreatable.
Audience Academic
Author Moodley, Mischka
Brink, Adrian John
Prentice, Elizabeth
Mendelson, Marc
Coetzee, Jennifer
Corcoran, Craig
Nordmann, Patrice
Poirel, Laurent
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Snippet The polymyxin antibiotic colistin is an antibiotic of last resort for the treatment of extensively drug-resistant Gram-negative bacteria, including...
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StartPage 35
SubjectTerms Adult
Aged
Animals
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Bacterial pneumonia
Care and treatment
Colistin - pharmacology
Drug resistance in microorganisms
Drug Resistance, Bacterial
Escherichia coli - drug effects
Escherichia coli - genetics
Escherichia coli Proteins - analysis
Female
Humans
Male
Meat - microbiology
Middle Aged
Plasmids
Pneumonia
Public Health
South Africa
Title Emergence of plasmid-mediated colistin resistance (MCR-1) among Escherichia coli isolated from South African patients
URI https://www.ncbi.nlm.nih.gov/pubmed/27138657
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Volume 106
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