Emergence of plasmid-mediated colistin resistance (MCR-1) among Escherichia coli isolated from South African patients

The polymyxin antibiotic colistin is an antibiotic of last resort for the treatment of extensively drug-resistant Gram-negative bacteria, including carbapenemase-producing Enterobacteriaceae. The State of the World's Antibiotics report in 2015 highlighted South Africa (SA)'s increasing inc...

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Published inSouth African medical journal Vol. 106; no. 5; p. 35
Main Authors Coetzee, Jennifer, Corcoran, Craig, Prentice, Elizabeth, Moodley, Mischka, Mendelson, Marc, Poirel, Laurent, Nordmann, Patrice, Brink, Adrian John
Format Journal Article
LanguageEnglish
Published South Africa Health & Medical Publishing Group 01.05.2016
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ISSN0256-9574
DOI10.7196/SAMJ.2016.v106i5.10710

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Summary:The polymyxin antibiotic colistin is an antibiotic of last resort for the treatment of extensively drug-resistant Gram-negative bacteria, including carbapenemase-producing Enterobacteriaceae. The State of the World's Antibiotics report in 2015 highlighted South Africa (SA)'s increasing incidence of these 'superbugs' (3.2% of Klebsiella pneumoniae reported from SA were carbapenemase producers), and in doing so, underscored SA's increasing reliance on colistin as a last line of defence. Colistin resistance effectively renders such increasingly common infections untreatable.
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ISSN:0256-9574
DOI:10.7196/SAMJ.2016.v106i5.10710