Current Evidence and Future Directions of Berberine Intervention in Depression
A major type of serious mood disorder, depression is currently a widespread and easily overlooked psychological illness. With the low side effects of natural products in the treatment of diseases becoming the pursuit of new antidepressants, natural Chinese medicine products have been paid more and m...
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| Published in | Frontiers in pharmacology Vol. 13; p. 824420 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
Frontiers Media S.A
23.05.2022
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| Online Access | Get full text |
| ISSN | 1663-9812 1663-9812 |
| DOI | 10.3389/fphar.2022.824420 |
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| Abstract | A major type of serious mood disorder, depression is currently a widespread and easily overlooked psychological illness. With the low side effects of natural products in the treatment of diseases becoming the pursuit of new antidepressants, natural Chinese medicine products have been paid more and more attention for their unique efficacy in improving depression. In a view from the current study, the positive antidepressant effects of berberine are encouraging. There is a lot of work that needs to be done to accurately elucidate the efficacy and mechanism of berberine in depression. In this review, the relevant literature reports on the treatment of depression and anxiety by berberine are updated, and the potential pharmacological mechanism of berberine in relieving depression has also been discussed. |
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| AbstractList | A major type of serious mood disorder, depression is currently a widespread and easily overlooked psychological illness. With the low side effects of natural products in the treatment of diseases becoming the pursuit of new antidepressants, natural Chinese medicine products have been paid more and more attention for their unique efficacy in improving depression. In a view from the current study, the positive antidepressant effects of berberine are encouraging. There is a lot of work that needs to be done to accurately elucidate the efficacy and mechanism of berberine in depression. In this review, the relevant literature reports on the treatment of depression and anxiety by berberine are updated, and the potential pharmacological mechanism of berberine in relieving depression has also been discussed. A major type of serious mood disorder, depression is currently a widespread and easily overlooked psychological illness. With the low side effects of natural products in the treatment of diseases becoming the pursuit of new antidepressants, natural Chinese medicine products have been paid more and more attention for their unique efficacy in improving depression. In a view from the current study, the positive antidepressant effects of berberine are encouraging. There is a lot of work that needs to be done to accurately elucidate the efficacy and mechanism of berberine in depression. In this review, the relevant literature reports on the treatment of depression and anxiety by berberine are updated, and the potential pharmacological mechanism of berberine in relieving depression has also been discussed.A major type of serious mood disorder, depression is currently a widespread and easily overlooked psychological illness. With the low side effects of natural products in the treatment of diseases becoming the pursuit of new antidepressants, natural Chinese medicine products have been paid more and more attention for their unique efficacy in improving depression. In a view from the current study, the positive antidepressant effects of berberine are encouraging. There is a lot of work that needs to be done to accurately elucidate the efficacy and mechanism of berberine in depression. In this review, the relevant literature reports on the treatment of depression and anxiety by berberine are updated, and the potential pharmacological mechanism of berberine in relieving depression has also been discussed. |
| Author | Sun, Zhi-Hui Zhu, Wen-Qian Guo, Yi Cui, Ran-Ji Ge, Tong-Tong Li, Bing-Jin Wu, Hui-Ying Li, Xin |
| AuthorAffiliation | 1 Jilin Provincial Key Laboratory on Molecular and Chemical Genetic , Second Hospital of Jilin University , Changchun , China 2 Department of Pharmacy, The Eastern Division of First Hospital of Jilin University , Changchun , China 3 Department of Breast Surgery , The Affiliated Hospital Changchun University of Chinese Medicine , Changchun , China |
| AuthorAffiliation_xml | – name: 3 Department of Breast Surgery , The Affiliated Hospital Changchun University of Chinese Medicine , Changchun , China – name: 1 Jilin Provincial Key Laboratory on Molecular and Chemical Genetic , Second Hospital of Jilin University , Changchun , China – name: 2 Department of Pharmacy, The Eastern Division of First Hospital of Jilin University , Changchun , China |
| Author_xml | – sequence: 1 givenname: Wen-Qian surname: Zhu fullname: Zhu, Wen-Qian – sequence: 2 givenname: Hui-Ying surname: Wu fullname: Wu, Hui-Ying – sequence: 3 givenname: Zhi-Hui surname: Sun fullname: Sun, Zhi-Hui – sequence: 4 givenname: Yi surname: Guo fullname: Guo, Yi – sequence: 5 givenname: Tong-Tong surname: Ge fullname: Ge, Tong-Tong – sequence: 6 givenname: Bing-Jin surname: Li fullname: Li, Bing-Jin – sequence: 7 givenname: Xin surname: Li fullname: Li, Xin – sequence: 8 givenname: Ran-Ji surname: Cui fullname: Cui, Ran-Ji |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35677435$$D View this record in MEDLINE/PubMed |
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| Copyright | Copyright © 2022 Zhu, Wu, Sun, Guo, Ge, Li, Li and Cui. Copyright © 2022 Zhu, Wu, Sun, Guo, Ge, Li, Li and Cui. 2022 Zhu, Wu, Sun, Guo, Ge, Li, Li and Cui |
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| Keywords | natural active ingredients bioamine depression berberine neuroplasticity |
| Language | English |
| License | Copyright © 2022 Zhu, Wu, Sun, Guo, Ge, Li, Li and Cui. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 This article was submitted to Ethnopharmacology, a section of the journal Frontiers in Pharmacology Reviewed by: Malcolm Hopwood, The University of Melbourne, Australia Qi Xu, Anhui Medical University, China Edited by: Fushun Wang, Nanjing University of Chinese Medicine, China |
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