Current Evidence and Future Directions of Berberine Intervention in Depression

A major type of serious mood disorder, depression is currently a widespread and easily overlooked psychological illness. With the low side effects of natural products in the treatment of diseases becoming the pursuit of new antidepressants, natural Chinese medicine products have been paid more and m...

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Published inFrontiers in pharmacology Vol. 13; p. 824420
Main Authors Zhu, Wen-Qian, Wu, Hui-Ying, Sun, Zhi-Hui, Guo, Yi, Ge, Tong-Tong, Li, Bing-Jin, Li, Xin, Cui, Ran-Ji
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 23.05.2022
Subjects
berberine
bioamine
depression
natural active ingredients
neuroplasticity
Pharmacology
natural active ingredients
bioamine
depression
berberine
neuroplasticity
Online AccessGet full text
ISSN1663-9812
1663-9812
DOI10.3389/fphar.2022.824420

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Summary:A major type of serious mood disorder, depression is currently a widespread and easily overlooked psychological illness. With the low side effects of natural products in the treatment of diseases becoming the pursuit of new antidepressants, natural Chinese medicine products have been paid more and more attention for their unique efficacy in improving depression. In a view from the current study, the positive antidepressant effects of berberine are encouraging. There is a lot of work that needs to be done to accurately elucidate the efficacy and mechanism of berberine in depression. In this review, the relevant literature reports on the treatment of depression and anxiety by berberine are updated, and the potential pharmacological mechanism of berberine in relieving depression has also been discussed.
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This article was submitted to Ethnopharmacology, a section of the journal Frontiers in Pharmacology
Reviewed by: Malcolm Hopwood, The University of Melbourne, Australia
Qi Xu, Anhui Medical University, China
Edited by: Fushun Wang, Nanjing University of Chinese Medicine, China
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2022.824420