Can MRI-derived depth of invasion predict nodal recurrence in oral tongue cancer?

• Published in: Oral radiology Vol. 37; no. 4; pp. 641 - 646
• Main Authors: Minamitake, Anri, Murakami, Ryuji, Sakamoto, Fumi, Yoshida, Ryoji, Sakata, Junki, Hirosue, Akiyuki, Kawahara, Kenta, Yamana, Keisuke, Nakayama, Hideki, Toya, Ryo, Shiraishi, Shinya
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.10.2021; Springer Nature B.V
• Subjects: Computed tomography; Dentistry; Head & neck cancer; Imaging; Magnetic resonance imaging; Medicine; Oral and Maxillofacial Surgery; Oral cancer; Oral carcinoma; Original Article; Patients; Population studies; Positron emission tomography; Radiology; Squamous cell carcinoma; Tomography; Tongue; F-fluorodeoxyglucose-positron emission tomography; Magnetic resonance imaging; Oral tongue cancer; Depth of invasion; Nodal recurrence; 18F-fluorodeoxyglucose-positron emission tomography
• ISSN: 0911-6028; 1613-9674; 1613-9674
• DOI: 10.1007/s11282-020-00505-3

Objectives To evaluate the prognostic value of preoperative radiological findings for nodal recurrence in clinically node-negative (cN0) patients with oral tongue squamous cell carcinoma (SCC). Methods The study population consisted of 52 patients with cT1-2N0 oral tongue SCC classified according to the 7th edition of the Union for International Cancer Control (UICC) staging system. The subjects had undergone preoperative radiological examinations, including magnetic resonance imaging (MRI) and 18 F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography. All patients were treated with local resection and watchful waiting for neck management. Using an unpaired t test, Pearson’s chi-squared test, and the Kaplan–Meier method, the MRI-derived depth of invasion (DOI), the standardized uptake value (SUV) on FDG-PET, and the T stage according to the 7th and 8th UICC were assessed as prognostic factors. Results The MRI-derived DOI was recorded as ≤ 5 mm in 24 patients and > 5 mm in 28 patients. During the follow-up period, nine patients exhibited nodal recurrence, with the MRI-derived DOI being significantly higher in patients with positive than in those with negative ( p  = 0.011). The SUV was not significant. Five-year cumulative nodal recurrence probabilities were 4.5% for patients with an MRI-derived DOI ≤ 5 mm, while it was 32.1% for > 5 mm ( p  = 0.013). Although the T classifications were not significant, none of our patients whose T stage according to the 8th UICC was T1 suffered nodal recurrence. Conclusions MRI-derived DOI can predict nodal recurrence, while preoperative information may assist in treatment planning for oral tongue SCC.