Hierarchical Spatio-Temporal Modeling of Naturalistic Functional Magnetic Resonance Imaging Signals via Two-Stage Deep Belief Network With Neural Architecture Search

• Published in: Frontiers in neuroscience Vol. 15; p. 794955
• Main Authors: Ren, Yudan, Xu, Shuhan, Tao, Zeyang, Song, Limei, He, Xiaowei
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 08.12.2021
• Subjects: deep belief network; functional brain network (FBN); hierarchical organization of brain function; naturalistic fMRI; neural architecture search; Neuroscience; deep belief network; functional brain network (FBN); neural architecture search; naturalistic fMRI; hierarchical organization of brain function
• ISSN: 1662-453X; 1662-4548; 1662-453X
• DOI: 10.3389/fnins.2021.794955

Naturalistic functional magnetic resonance imaging (NfMRI) has become an effective tool to study brain functional activities in real-life context, which reduces the anxiety or boredom due to difficult or repetitive tasks and avoids the problem of unreliable collection of brain activity caused by the subjects’ microsleeps during resting state. Recent studies have made efforts on characterizing the brain’s hierarchical organizations from fMRI data by various deep learning models. However, most of those models have ignored the properties of group-wise consistency and inter-subject difference in brain function under naturalistic paradigm. Another critical issue is how to determine the optimal neural architecture of deep learning models, as manual design of neural architecture is time-consuming and less reliable. To tackle these problems, we proposed a two-stage deep belief network (DBN) with neural architecture search (NAS) combined framework (two-stage NAS-DBN) to model both the group-consistent and individual-specific naturalistic functional brain networks (FBNs), which reflected the hierarchical organization of brain function and the nature of brain functional activities under naturalistic paradigm. Moreover, the test-retest reliability and spatial overlap rate of the FBNs identified by our model reveal better performance than that of widely used traditional methods. In general, our model provides a promising method for characterizing hierarchical spatiotemporal features under the natural paradigm.