Evaluation and Preparation of a Designed Kartogenin Drug Delivery System (DDS) of Hydrazone-Linkage-Based pH Responsive mPEG-Hz-b-PCL Nanomicelles for Treatment of Osteoarthritis
Osteoarthritis (OA) is a chronic disease caused by the damage of articular cartilage. Kartogenin (KGN) is a well-recognized small molecule which could induce MSCs chondrogenesis and promote cartilage repair treatments. Nano-level micells could be a suitable drug carrier technology for the treatments...
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| Published in | Frontiers in bioengineering and biotechnology Vol. 10; p. 816664 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
Frontiers Media S.A
09.03.2022
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| Subjects | |
| Online Access | Get full text |
| ISSN | 2296-4185 2296-4185 |
| DOI | 10.3389/fbioe.2022.816664 |
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| Summary: | Osteoarthritis (OA) is a chronic disease caused by the damage of articular cartilage. Kartogenin (KGN) is a well-recognized small molecule which could induce MSCs chondrogenesis and promote cartilage repair treatments. Nano-level micells could be a suitable drug carrier technology for the treatments. In this study, the acid-responsive methoxy poly(ethylene oxide)-hydrazone-poly(ε-caprolactone) copolymers, mPEG-Hz-
b
-PCL, were synthesized. The structure was characterized by
1
H NMR. The evaluation of a designed kartogenin drug delivery system (DDS) of hydrazone-linkage-based pH responsive mPEG-Hz-
b
-PCL nanomicelles for treatment of osteoarthritis could be carried out. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 This article was submitted to Biomaterials, a section of the journal Frontiers in Bioengineering and Biotechnology Reviewed by: Wen-Hsuan Chiang, National Chung Hsing University, Taiwan Edited by: Yi-Chen Ethan Li, Feng Chia University, Taiwan Feng-Huei Lin, National Taiwan University, Taiwan |
| ISSN: | 2296-4185 2296-4185 |
| DOI: | 10.3389/fbioe.2022.816664 |