Kikuchi–Fujimoto Disease Post COVID-19 Vaccination: Case Report and Review of Literature

• Published in: Vaccines (Basel) Vol. 9; no. 11; p. 1251
• Main Authors: Tan, Hui Min, Hue, Susan Swee-Shan, Wee, Aileen, See, Kay Choong
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 29.10.2021; MDPI
• Subjects: Analgesics; Antibodies; Antigens; Biopsy; Case Report; Case reports; Conflicts of interest; Coronaviruses; COVID-19; COVID-19 vaccine; COVID-19 vaccines; Etiology; Fever; Hepatitis; Histology; Hyperplasia; Infections; Kikuchi–Fujimoto disease; Leukopenia; Literature reviews; Lymphadenitis; Lymphadenopathy; Lymphatic system; necrotizing histiocytic lymphadenitis; Neutrophils; Pandemics; Patients; Severe acute respiratory syndrome coronavirus 2; Side effects; Ultrasonic imaging; Viral diseases
• ISSN: 2076-393X; 2076-393X
• DOI: 10.3390/vaccines9111251

With the rapid development of various coronavirus disease 2019 (COVID-19) vaccines in a bid to counter and contain the COVID-19 pandemic, unusual and uncommon side effects of COVID-19 vaccination have been increasingly reported in the literature. Ipsilateral lymphadenopathy is a fairly common side effect of vaccination of any kind, with its etiology most commonly related to reactive lymphadenopathy. However, Kikuchi–Fujimoto Disease (KFD) or necrotizing histiocytic lymphadenitis is rarely observed post-vaccination, with only one other case of KFD post COVID-19 vaccination reported to date. We report two more cases of KFD post COVID-19 vaccination in the Asian population, highlighting the clinical course and salient clinical, radiological and histologic findings. In addition, we provide a literature review of the existing cases of lymphadenopathy post COVID-19 vaccination with cytologic and/or histologic correlation.