Six-month clinical outcomes after below-the-knee angioplasty for critical limb ischemia in patients on hemodialysis

• Published in: Cardiovascular intervention and therapeutics Vol. 25; no. 2; pp. 91 - 97
• Main Authors: Nakano, Masatsugu, Muramatsu, Toshiya, Hirano, Keisuke, Tsukahara, Reiko, Itou, Yoshiaki, Ishimori, Hiroshi
• Format: Journal Article
• Language: English
• Published: Japan Springer Japan 01.07.2010
• Subjects: Angioplasty; Cardiology; Critical limb ischemia; Hemodialysis; Interventional Radiology; Medicine; Medicine & Public Health; Original Article; Hemodialysis; Angioplasty; Critical limb ischemia
• ISSN: 1868-4300; 1868-4297
• DOI: 10.1007/s12928-010-0018-z

To evaluate 6-month clinical outcomes after below-the-knee (BTK) angioplasty for critical limb ischemia (CLI) in patients on hemodialysis (HD). Subjects were 69 serial patients (81 limbs, 123 vessels) who underwent percutaneous transluminal angioplasty (PTA) for primary treatment of infrapopliteal lesions in CLI from June 2004 to December 2008. Subjects were classified into two groups for the comparative study of clinical outcomes: the patients on HD: the HD group (35 patients, 45 limbs, 71 vessels, 66 ± 11 years) and the patients not on HD: the non-HD group (34 patients, 36 limbs, 52 vessels, 69 ± 9 years). A non-randomized retrospective comparative study was conducted to obtain clinical outcomes at 6 months. In clinical results at 6 months, a higher percentage of tendency toward repeat PTA for the treated leg in the HD group (28.9 vs. 11.1%, p  = 0.059), but it was not statistically significant. There was no significant difference in the rate of major amputation (11.1 vs. 5.5%) between the two groups. However, the percentage of repeat PTA performed twice or more times (13.3 vs. 0%, p  = 0.031) and all-cause mortality (17.1 vs. 0%, p  = 0.012) in the HD group was significantly higher than in the non-HD group. The HD group had a significantly lower rate of freedom from all-cause mortality, major amputation, or repeat PTA in the 6-month follow-up compared to the non-HD group, with the HD group 51.4% and the non-HD group 85.3% (logrank test p  = 0.003). Although there are more HD patients requiring repeat revascularization compared to the general population, the 6-month outcomes of limb salvage after BTK angioplasty for CLI in HD patients were not significantly different from the general population.