Unraveling the Predictors for Delirium and ICU Stay Duration in Patients with Heart Failure and Reduced Ejection Fraction (HFrEF) Undergoing Coronary Artery Bypass Grafting—A Multicentric Analysis

• Published in: Biomedicines Vol. 12; no. 4; p. 749
• Main Authors: Rustenbach, Christian Jörg, Reichert, Stefan, Berger, Rafal, Schano, Julia, Nemeth, Attila, Haeberle, Helene, Charotte, Christophe, Caldonazo, Tulio, Saqer, Ibrahim, Saha, Shekhar, Schnackenburg, Philipp, Djordjevic, Ilija, Krasivskyi, Ihor, Wendt, Stefanie, Serna-Higuita, Lina Maria, Doenst, Torsten, Hagl, Christian, Wahlers, Thorsten, Schlensak, Christian, Sandoval Boburg, Rodrigo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.04.2024
• Subjects: Analysis; Bypass; CABG; Cardiac patients; Care and treatment; Comparative analysis; Complications; Complications and side effects; Congestive heart failure; Coronary artery; Coronary vessels; Critical care; Delirium; Ejection fraction; Germany; Health care; Heart attacks; Heart failure; Heart surgery; HFrEF; Hospitals; ICU stay; Intensive care; Length of stay; Mortality; OPCAB; Patients; Postoperative; postoperative delirium; Regression analysis; Resource utilization; Statistical analysis; Surgical techniques; Survival analysis; Variables; Veins & arteries; Germany; heart failure; ICU stay; CABG; postoperative delirium; HFrEF; OPCAB
• ISSN: 2227-9059; 2227-9059
• DOI: 10.3390/biomedicines12040749

Objective: This study assesses predictors for postoperative delirium (POD) and ICU stay durations in HFrEF patients undergoing CABG, focusing on ONCAB versus OPCAB surgical methods. Summary Background Data: In cardiac surgery, especially CABG, POD significantly impacts patient recovery and healthcare resource utilization. With varying incidences based on surgical techniques, this study provides an in-depth analysis of POD in the context of HFrEF patients, a group particularly susceptible to this complication. Methods: A retrospective analysis of 572 patients who underwent isolated CABG surgery with a preoperative ejection fraction under 40% was conducted at four German university hospitals. Patients were categorized into ONCAB and OPCAB groups for comparative analysis. Results: Age and Euro Score II were significant predictors of POD. The ONCAB group showed higher incidences of re-sternotomy (OR: 3.37), ECLS requirement (OR: 2.29), and AKI (OR: 1.49), whereas OPCAB was associated with a lower incidence of delirium. Statistical analysis indicated a significant difference in ICU stay durations between the two groups, influenced by surgical complexity and postoperative complications. Conclusions: This study underscores the importance of surgical technique in determining postoperative outcomes in HFrEF patients undergoing CABG. OPCAB may offer advantages in reducing POD incidence. These findings suggest the need for tailored surgical decisions and comprehensive care strategies to enhance patient recovery and optimize healthcare resources.