Synergistic Effect of Lupenone and Caryophyllene Oxide against Trypanosoma cruzi

The in vitro trypanocidal activity of a 1 : 4 mixture of lupenone and caryophyllene oxide confirmed a synergistic effect of the terpenoids against epimastigotes forms of T. cruzi (IC50=10.4 μg/mL, FIC = 0.46). In addition, testing of the terpenoid mixture for its capacity to reduce the number of ama...

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Published inEvidence-based complementary and alternative medicine Vol. 2013; no. 2013; pp. 1 - 6
Main Authors Polanco-Hernández, Glendy, Escalante-Erosa, Fabiola, García-Sosa, Karlina, Rosado, María E., Guzmán-Marín, Eugenia del S., Acosta Viana, Karla Y., Giménez-Turba, Alberto, Salamanca, Efraín, Peña-Rodríguez, Luis Manuel
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Puplishing Corporation 01.01.2013
Hindawi Publishing Corporation
John Wiley & Sons, Inc
Subjects
Antimicrobial agents
Caryophyllene
Caryophyllene oxide
Chemotherapy
Cytotoxicity
Disease
Drug dosages
Epimastigotes
Natural products
Nests
Parasites
Protozoa
Skeletal muscle
Tropical diseases
Trypanosoma cruzi
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ISSN1741-427X
1741-4288
DOI10.1155/2013/435398

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Summary:The in vitro trypanocidal activity of a 1 : 4 mixture of lupenone and caryophyllene oxide confirmed a synergistic effect of the terpenoids against epimastigotes forms of T. cruzi (IC50=10.4 μg/mL, FIC = 0.46). In addition, testing of the terpenoid mixture for its capacity to reduce the number of amastigote nests in cardiac tissue and skeletal muscle of infected mice showed a reduction of more than 80% at a dose level of 20.8 mg·kg−1·day−1.
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Academic Editor: Roser Vila
ISSN:1741-427X
1741-4288
DOI:10.1155/2013/435398