Effect of Various Preterm Infant Milk Formulas on NEC-Like Gut Injury in Mice

Formula feeding is an important risk factor for the development of necrotizing enterocolitis in preterm infants. The potential harmful effects of different preterm formulas on the developing intestinal tract remain incompletely understood. Here we demonstrate that feeding newborn mouse pups with var...

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Published inFrontiers in pediatrics Vol. 10; p. 902798
Main Authors Rao, Karishma, Cuna, Alain, Chavez-Bueno, Susana, Menden, Heather, Yu, Wei, Ahmed, Ishfaq, Srinivasan, Pugazhendhi, Umar, Shahid, Sampath, Venkatesh
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 06.07.2022
Subjects
formula
intestinal microbiome
necrotizing enterocolitis (NEC)
Pediatrics
prematurity
probiotics
necrotizing enterocolitis (NEC)
formula
prematurity
intestinal microbiome
probiotics
Online AccessGet full text
ISSN2296-2360
2296-2360
DOI10.3389/fped.2022.902798

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Summary:Formula feeding is an important risk factor for the development of necrotizing enterocolitis in preterm infants. The potential harmful effects of different preterm formulas on the developing intestinal tract remain incompletely understood. Here we demonstrate that feeding newborn mouse pups with various preterm formulas resulted in differing effects on intestinal inflammation, apoptosis, and activation of the pro-inflammatory transcription factor NFκB. 16S rRNA sequencing revealed that each preterm formula resulted in significant gut microbial alterations that were different from dam-fed controls. Formula feeding with EleCare and Similac Special Care caused greater intestinal injury compared to NeoSure. Pre-treatment with Lactobacillus rhamnosus GG ameliorated severity of intestinal injury from EleCare and Similac Special Care. Our findings indicate that not all preterm formulas are the same, and different formulations can have varying effects on intestinal inflammation, apoptosis, and microbiome composition.
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Edited by: Yuying Liu, University of Texas Health Science Center at Houston, United States
This article was submitted to Neonatology, a section of the journal Frontiers in Pediatrics
These authors have contributed equally to this work
Reviewed by: Misty Good, University of North Carolina at Chapel Hill, United States; Douglas G. Burrin, United States Department of Agriculture (USDA), United States
ISSN:2296-2360
2296-2360
DOI:10.3389/fped.2022.902798