Application of aptamers for assessment of vaccine efficacy
Assessing antigen concentration of vaccine is essential step in determining the quality of the vaccine prior to vaccination. After vaccination, vaccine-induced antibody titer should also be measured to verify the vaccine efficacy. Since conventional assay used for vaccine concentrations and induced...
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| Published in | Clinical and experimental vaccine research (Seoul) Vol. 6; no. 2; pp. 160 - 163 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Korea (South)
Korean Vaccine Society
01.07.2017
The Korean Vaccine Society 대한백신학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2287-3651 2287-366X |
| DOI | 10.7774/cevr.2017.6.2.160 |
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| Abstract | Assessing antigen concentration of vaccine is essential step in determining the quality of the vaccine prior to vaccination. After vaccination, vaccine-induced antibody titer should also be measured to verify the vaccine efficacy. Since conventional assay used for vaccine concentrations and induced Ab-titers is antibody-based enzyme-linked immunosorbent assay, the assay inevitably brings drawbacks of antibody such as high cost for production, limited stability, and inconsistent quality between lot-to-lots. Aptamer is single-stranded nucleic acid having three-dimensional structure and has features overcoming limitations of antibody. This review will briefly introduce the features of aptamer and potential of aptamer-based system for evaluation of vaccine efficacy. |
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| AbstractList | Assessing antigen concentration of vaccine is essential step in determining the quality of the vaccine prior to vaccination. After vaccination, vaccine-induced antibody titer should also be measured to verify the vaccine efficacy. Since conventional assay used for vaccine concentrations and induced Ab-titers is antibody-based enzyme-linked immunosorbent assay, the assay inevitably brings drawbacks of antibody such as high cost for production, limited stability, and inconsistent quality between lot-to-lots. Aptamer is single-stranded nucleic acid having three-dimensional structure and has features overcoming limitations of antibody. This review will briefly introduce the features of aptamer and potential of aptamer-based system for evaluation of vaccine efficacy. Assessing antigen concentration of vaccine is essential step in determining the quality of the vaccine prior to vaccination. After vaccination, vaccine-induced antibody titer should also be measured to verify the vaccine efficacy. Since conventional assay used for vaccine concentrations and induced Ab-titers is antibody-based enzyme-linked immunosorbent assay, the assay inevitably brings drawbacks of antibody such as high cost for production, limited stability, and inconsistent quality between lot-to-lots. Aptamer is single-stranded nucleic acid having three-dimensional structure and has features overcoming limitations of antibody. This review will briefly introduce the features of aptamer and potential of aptamer-based system for evaluation of vaccine efficacy. KCI Citation Count: 0 Assessing antigen concentration of vaccine is essential step in determining the quality of the vaccine prior to vaccination. After vaccination, vaccine-induced antibody titer should also be measured to verify the vaccine efficacy. Since conventional assay used for vaccine concentrations and induced Ab-titers is antibody-based enzyme-linked immunosorbent assay, the assay inevitably brings drawbacks of antibody such as high cost for production, limited stability, and inconsistent quality between lot-to-lots. Aptamer is single-stranded nucleic acid having three-dimensional structure and has features overcoming limitations of antibody. This review will briefly introduce the features of aptamer and potential of aptamer-based system for evaluation of vaccine efficacy.Assessing antigen concentration of vaccine is essential step in determining the quality of the vaccine prior to vaccination. After vaccination, vaccine-induced antibody titer should also be measured to verify the vaccine efficacy. Since conventional assay used for vaccine concentrations and induced Ab-titers is antibody-based enzyme-linked immunosorbent assay, the assay inevitably brings drawbacks of antibody such as high cost for production, limited stability, and inconsistent quality between lot-to-lots. Aptamer is single-stranded nucleic acid having three-dimensional structure and has features overcoming limitations of antibody. This review will briefly introduce the features of aptamer and potential of aptamer-based system for evaluation of vaccine efficacy. |
| Author | Gee, Grace Yoon, Soo Young Seo, Sang-Hwan Hong, Kee-Jong |
| AuthorAffiliation | INTERPARK Bio-Convergence Center, Seoul, Korea |
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| Cites_doi | 10.1158/0008-5472.CAN-10-0568 10.1073/pnas.1502159112 10.1186/s13036-017-0054-7 10.1016/j.trac.2007.12.004 10.1016/j.bios.2014.09.026 10.3390/pathogens3020341 10.1016/j.bioeng.2007.06.001 10.1016/j.amsu.2014.09.001 10.2174/1568026615666150413154038 10.1021/ac8006957 10.1038/srep10897 10.1007/s00216-007-1587-2 |
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| Keywords | Antibodies Antigens Vaccines Enzyme-linked immunosorbent assay Aptamers |
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| SubjectTerms | Antibodies Biosensors Brief Communication Enzymes Immunization Ligands Pathogens Quantum dots Signal to noise ratio Vaccines 예방의학 |
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| Title | Application of aptamers for assessment of vaccine efficacy |
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