Prediction of False-Positive Recognition Errors During Wada Testing

• Published in: Journal of clinical and experimental neuropsychology Vol. 28; no. 7; pp. 1065 - 1072
• Main Authors: Barr, William B., Raghavan, Manoj, Kim Nelson, Peter, Devinsky, Orrin
• Format: Journal Article
• Language: English
• Published: Colchester Taylor & Francis Group 01.10.2006; Taylor & Francis
• Subjects: Adult; Amobarbital - pharmacology; Biological and medical sciences; Cerebral Dominance; Dose-Response Relationship, Drug; Electroencephalography - methods; Error Analysis; False Positive Reactions; Female; Humans; Hypnotics and Sedatives - pharmacology; Language; Language Tests; Male; Medical sciences; Memory; Neuropsychological Tests - statistics & numerical data; Patients; Predictive Value of Tests; Psychology. Psychoanalysis. Psychiatry; Psychometrics. Diagnostic aid systems; Psychopathology. Psychiatry; Recognition; Recognition (Psychology) - drug effects; Recognition (Psychology) - physiology; Regression Analysis; Techniques and methods; Tests; Verbal Learning; Verbal Learning - drug effects; Verbal Learning - physiology; Human; False positive; Prediction; Neuropsychological test; Psychometrics; Amobarbital; Hypnotic; Sedative; Barbiturates; California Verbal Learning Test; Recognition
• ISSN: 1380-3395; 1744-411X
• DOI: 10.1080/13803390500205692

False-positive (FP) errors during recognition memory testing often interfere with interpretation of Wada test results. This study examined which clinical and neuropsychological variables provide the best prediction of these errors. Fifty-six patients completed the Wada test and the California Verbal Learning Test (CVLT). Subjects with three or more FP errors on the recognition trials of the CVLT were nearly twice as likely to exhibit FP responding during the Wada test. Further analysis indicates that FP errors during the Wada test appear to be the primary result of a stable and liberal response-bias rather than a result of any other neurological or procedure-related factor.