EnigmaVis: Online Interactive Visualization of Genome-Wide Association Studies of the Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium

In an attempt to increase power to detect genetic associations with brain phenotypes derived from human neuroimaging data, we recently conducted a large-scale, genome-wide association meta-analysis of hippocampal, brain, and intracranial volume through the Enhancing NeuroImaging Genetics through Met...

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Bibliographic Details
Published inTwin research and human genetics Vol. 15; no. 3; pp. 414 - 418
Main Authors Novak, Nic M., Stein, Jason L., Medland, Sarah E., Hibar, Derrek P., Thompson, Paul M., Toga, Arthur W.
Format Journal Article
LanguageEnglish
Published Cambridge, UK Cambridge University Press 01.06.2012
Subjects
Brain - anatomy & histology
Brain - physiology
Computer applications
Databases, Genetic
Genome-Wide Association Study
Humans
Internet
Medical technology
Meta-Analysis as Topic
Neuroimaging
Online tools
Phenotype
visualization
GWAS
genetics
SNP
neuroimaging
Online AccessGet full text
ISSN1832-4274
1839-2628
DOI10.1017/thg.2012.17

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Summary:In an attempt to increase power to detect genetic associations with brain phenotypes derived from human neuroimaging data, we recently conducted a large-scale, genome-wide association meta-analysis of hippocampal, brain, and intracranial volume through the Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) consortium. Here, we present a freely available online interactive tool, EnigmaVis, which makes it easy to visualize the association results generated by the consortium alongside allele frequency, genes, and functional annotations. EnigmaVis runs natively within the web browser, and generates plots that show the level of association between brain phenotypes at user-specified genomic positions. Uniquely, EnigmaVis is dynamic; users can interact with elements on the plot in real time. This software will be useful when exploring the effect on brain structure of particular genetic variants influencing neuropsychiatric illness and cognitive function. Future projects of the consortium and updates to EnigmaVis will also be displayed on the site. EnigmaVis is freely available online at http://enigma.loni.ucla.edu/enigma-vis/
Bibliography:Twin Research and Human Genetics, v.15, no.3, June 2012: 414-418
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ISSN:1832-4274
1839-2628
DOI:10.1017/thg.2012.17