Radiological assessment of hepatic vein invasion by hepatocellular carcinoma using combined computed tomography hepatic arteriography and computed tomography arterial portography

• Published in: Japanese Journal of Radiology Vol. 28; no. 6; pp. 414 - 422
• Main Authors: Nishie, Akihiro, Tajima, Tsuyoshi, Asayama, Yoshiki, Ishigami, Kousei, Hirakawa, Masakazu, Ushijima, Yasuhiro, Kakihara, Daisuke, Okamoto, Daisuke, Fujita, Nobuhiro, Taketomi, Akinobu, Yoshimitsu, Kengo, Honda, Hiroshi
• Format: Journal Article
• Language: English
• Published: Japan Springer Japan 01.07.2010; Springer Nature B.V
• Subjects: Aged; Carcinoma, Hepatocellular - diagnostic imaging; Contrast Media; Female; Hepatic Veins - diagnostic imaging; Humans; Imaging; Iopamidol; Liver Neoplasms - diagnostic imaging; Male; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Invasiveness - diagnostic imaging; Nuclear Medicine; Observer Variation; Original Article; Portography - methods; Radiographic Image Enhancement - methods; Radiology; Radiotherapy; Retrospective Studies; Tomography, X-Ray Computed - methods; Vascular Neoplasms - diagnostic imaging; HCC; Hepatocellular carcinoma; Hepatic venous invasion; CTHA; CTAP
• ISSN: 1867-1071; 1867-108X; 1862-5274; 1867-108X
• DOI: 10.1007/s11604-010-0442-0

Purpose The aim of this study was to elucidate computed tomography hepatic arteriography (CTHA) and CT arterial portography (CTAP) findings characteristic of hepatocellular carcinoma (HCC) with large hepatic venous invasion (HVI) and then to examine whether the presence of minute HVI can be diagnosed based on each finding. Materials and methods Combined CTHA and CTAP of 106 HCCs were examined. Two radiologists analyzed the radiological findings of five nodules with large HVI (group vv2). The remaining 101 nodules were classified into two groups: group vv1, positive minute HVI; group vv0, negative HVI. They examined whether each finding observed in group vv2 could be detected in groups vv1 and vv0. Results Analysis of group vv2 identified (a) tumor thrombus, (b) early inflow of the contrast into the hepatic vein proximal to the invaded site, and (c) partially decreased portal venous flow in the peripheral parenchyma subject to the involved hepatic vein. Findings (b) and (c) were observed in 16% of group vv1. A significant difference in frequency of finding (c) was obtained between groups vv1 and vv0. The positive and negative predictive values of finding (c) were 66.7% and 77.9%, respectively. Conclusion Findings (b) and (c), especially the latter, may partly contribute to the radiological diagnosis of minute HVI.