Tissue perfusion rate estimation with compression-based photoacoustic-ultrasound imaging

• Published in: Journal of biomedical optics Vol. 23; no. 1; p. 016010
• Main Authors: Choi, Min, James Shapiro, A. M, Zemp, Roger
• Format: Journal Article
• Language: English
• Published: United States Society of Photo-Optical Instrumentation Engineers 01.01.2018
• Subjects: Algorithms; Data Compression - methods; Hand - blood supply; Hand - diagnostic imaging; Hemodynamics - physiology; Humans; Perfusion Imaging - methods; Photoacoustic Techniques - methods; Ultrasonography - methods; ultrasound imaging; perfusion; photoacoustic imaging; hemodynamics
• ISSN: 1083-3668; 1560-2281; 1560-2281
• DOI: 10.1117/1.JBO.23.1.016010

Tissue perfusion is essential for transporting blood oxygen and nutrients. Measurement of tissue perfusion rate would have a significant impact in clinical and preclinical arenas. However, there are few techniques to image this important parameter and they typically require contrast agents. A label-free methodology based on tissue compression and imaging with a high-frequency photoacoustic-ultrasound system is introduced for estimating and visualizing tissue perfusion rates. Experiments demonstrate statistically significant differences in depth-resolved perfusion rates in a human subject with various temperature exposure conditions.