Cell cycle in sporadic melanoma

• Published in: International journal of dermatology Vol. 41; no. 9; pp. 550 - 556
• Main Authors: Czajkowski, Rafał, Drewa, Tomasz, Woźniak, Alina, Krzyżyńska-Malinowska, Ewa
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.09.2002; Blackwell Science; Blackwell Publishing Ltd
• Subjects: Biological and medical sciences; Cell Cycle - genetics; Cell Cycle - physiology; Dermatology; G1 Phase - genetics; G1 Phase - physiology; Genes, cdc - physiology; Humans; Medical sciences; Melanoma - genetics; Melanoma - physiopathology; Skin Neoplasms - genetics; Skin Neoplasms - physiopathology; Tumors of the skin and soft tissue. Premalignant lesions; Human; Skin disease; Sporadic; Check; Malignant tumor; Review; Carcinogenesis; G1 Phase; Regulation(control); C-Onc gene; Cell cycle; Malignant melanoma; Skin; Molecular biology; Protooncogene; Tumor suppressor gene
• ISSN: 0011-9059; 1365-4632
• DOI: 10.1046/j.1365-4362.2002.01601.x

Sporadic melanoma is a neoplasm whose etiology has not been fully investigated. Contemporary achievements in molecular biology have made it possible to localize the genes whose damage can contribute to the initiation of neoplastic transformation of melanocytes and lead to a progression of the disease. The majority of these genes are responsible for the correct progression of phase G1 of the cell cycle. Phase G1 of the cell cycle is subject to control by many protooncogenes and antioncogenes, which constitute the pRb or p53 pathway, damage to which can lead to the development of malignant melanoma. The present paper discusses disorders in the control of phase G1 of the cell cycle in sporadic melanoma.