The effect of antioxidant status on overall survival in renal cell carcinoma

• Published in: Archives of medical science Vol. 16; no. 1; pp. 94 - 101
• Main Authors: Pavlović, Ivan, Pejić, Snežana, Radojević-Škodrić, Sanja, Todorović, Ana, Stojiljković, Vesna, Gavrilović, Ljubica, Popović, Nataša, Basta-Jovanović, Gordana, Džamić, Zoran, Pajović, Snežana B.
• Format: Journal Article
• Language: English
• Published: Poland Termedia Publishing House 01.01.2020
• Subjects: Clinical Research; overall survival; oxidative stress; prospective study; renal cell carcinoma; overall survival; renal cell carcinoma; prospective study; oxidative stress
• ISSN: 1734-1922; 1896-9151
• DOI: 10.5114/aoms.2019.86818

The oxidative stress contributes to all three phases of carcinogenesis and represents a concomitant condition in renal cell carcinoma (RCC). RCC is the most common type of neoplasm of the kidney, and despite numerous studies the set of predictive and prognostic markers of survival are still unknown. The aim of our study was to examine the relation between antioxidant (AO) status and overall survival (OS) in RCC patients. Our study included 95 patients with RCC, who underwent radical nephrectomy. We analysed the prognostic role of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase, glutathione reductase, glutathione, and malondialdehyde) and other clinicopathological factors (size, grade, stage, and histological subtype) on the OS of RCC patients. The 5-year OS was 54.6%. The survival analysis related to AO parameters showed no significant difference in survival of RCC patients. The concentration of malondialdehyde, an indicator of lipid peroxidation, also had no significant effect on the survival rate of RCC patients. Univariate and multivariate analysis confirmed the significance of clinicopathological parameters (size, < 0.001; Fuhrman grade, = 0.001, and stage, < 0.001) for patients' survival. In our cohort of patients, different antioxidant parameters were not found to be predictors for OS of patients with RCC, who underwent radical nephrectomy.