Arrhythmogenic Phenotype in Dilated Cardiomyopathy: Natural History and Predictors of Life‐Threatening Arrhythmias

• Published in: Journal of the American Heart Association Vol. 4; no. 10; p. e002149
• Main Authors: Spezzacatene, Anita, Sinagra, Gianfranco, Merlo, Marco, Barbati, Giulia, Graw, Sharon L., Brun, Francesca, Slavov, Dobromir, Di Lenarda, Andrea, Salcedo, Ernesto E., Towbin, Jeffrey A., Saffitz, Jeffrey E., Marcus, Frank I., Zareba, Wojciech, Taylor, Matthew R. G., Mestroni, Luisa
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 16.10.2015
• Subjects: Adult; Arrhythmias, Cardiac - diagnosis; Arrhythmias, Cardiac - etiology; Arrhythmias, Cardiac - mortality; Arrhythmias, Cardiac - physiopathology; Arrhythmias, Cardiac - therapy; Cardiomyopathy, Dilated - complications; Cardiomyopathy, Dilated - diagnosis; Cardiomyopathy, Dilated - mortality; Cardiomyopathy, Dilated - physiopathology; Cardiomyopathy, Dilated - therapy; Cause of Death; Death, Sudden, Cardiac - etiology; Death, Sudden, Cardiac - prevention & control; Disease Progression; Disease-Free Survival; Electrocardiography, Ambulatory; Female; Heart Transplantation; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Original Research; Phenotype; Prevalence; Registries; Risk Factors; Severity of Illness Index; Time Factors; sudden death; cardiomyopathy; prognosis; arrhythmia
• ISSN: 2047-9980; 2047-9980
• DOI: 10.1161/JAHA.115.002149

Patients with dilated cardiomyopathy (DCM) may present with ventricular arrhythmias early in the disease course, unrelated to the severity of left ventricular dysfunction. These patients may be classified as having an arrhythmogenic DCM (AR-DCM). We investigated the phenotype and natural history of patients with AR-DCM. Two hundred eighty-five patients with a recent diagnosis of DCM (median duration of the disease 1 month, range 0 to 7 months) and who had Holter monitoring at baseline were comprehensively evaluated and followed for 107 months (range 29 to 170 months). AR-DCM was defined by the presence of ≥1 of the following: unexplained syncope, rapid nonsustained ventricular tachycardia (≥5 beats, ≥150 bpm), ≥1000 premature ventricular contractions/24 hours, and ≥50 ventricular couplets/24 hours, in the absence of overt heart failure. The primary end points were sudden cardiac death (SCD), sustained ventricular tachycardia (SVT), or ventricular fibrillation (VF). The secondary end points were death from congestive heart failure or heart transplantation. Of the 285 patients, 109 (38.2%) met criteria for AR-DCM phenotype. AR-DCM subjects had a higher incidence of SCD/SVT/VF compared with non-AR-DCM patients (30.3% vs 17.6%, P=0.022), with no difference in the secondary end points. A family history of SCD/SVT/VF and the AR-DCM phenotype were statistically significant and cumulative predictors of SCD/SVT/VF. One-third of DCM patients may have an arrhythmogenic phenotype associated with increased risk of arrhythmias during follow-up. A family history of ventricular arrhythmias in DCM predicts a poor prognosis and increased risk of SCD.