Are core component processes of executive function dissociable within the frontal lobes? Evidence from humans with focal prefrontal damage

• Published in: Cortex Vol. 49; no. 7; pp. 1790 - 1800
• Main Authors: Tsuchida, Ami, Fellows, Lesley K.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.07.2013; Elsevier
• Subjects: Adult and adolescent clinical studies; Attention; Attention - physiology; Biological and medical sciences; Brain Mapping; Cognitive control; Comprehension - physiology; Educational Status; Executive function; Executive Function - physiology; Female; Frontal Lobe - injuries; Frontal Lobe - physiology; Humans; Image Processing, Computer-Assisted; Intelligence Tests; Magnetic Resonance Imaging; Male; Medical sciences; Middle Aged; Neuropsychological Tests; Organic mental disorders. Neuropsychology; Prefrontal cortex; Prefrontal Cortex - injuries; Prefrontal Cortex - pathology; Psychology. Psychoanalysis. Psychiatry; Psychomotor Performance - physiology; Psychopathology. Psychiatry; Reaction Time - physiology; Space Perception - physiology; Stroke - complications; Stroke - pathology; Stroke - psychology; Stroop Test; Working memory; Executive function; Prefrontal cortex; Working memory; Cognitive control; Human; Nervous system diseases; Frontal lobe; Central nervous system disease; Central nervous system; Cognition; Encephalon; Cerebral disorder
• ISSN: 0010-9452; 1973-8102; 1973-8102
• DOI: 10.1016/j.cortex.2012.10.014

Executive function encompasses a range of control processes supporting flexible, goal-directed behaviour. Attentional set-shifting, updating of information in working memory, and inhibitory control have been proposed as key components of executive function, but debate continues as to the validity of this conceptual framework, and the neural substrates of these putative components. Here we examined prefrontal structure–function relationships for each of these component processes in a large cohort of patients with focal prefrontal damage. Forty-five patients with focal damage to various sectors of prefrontal cortex (PFC), and 50 demographically matched healthy control subjects performed an attention shifting task, the Stroop colour naming task, and a spatial search task. Voxel-based lesion–symptom mapping revealed that damage to left ventrolateral PFC led to impaired performance on both the Stroop and attention shifting tasks. In contrast, performance of the spatial search task depended on several regions within PFC, but notably not left ventrolateral PFC. These observations were confirmed with direct comparison of performance between patients grouped according to lesion location. This dissociation partly supports the component process view of executive function, distinguishing the goal-directed regulation of attention (perhaps specifically in the verbal domain) from the requirements of the spatial search task, including the updating of information in spatial working memory. These findings are easier to reconcile with modular, material-specific accounts than with more unitary models of executive function.