Body mass index and myocardium at risk in patients with acute coronary syndrome

Whilst traditional studies have shown that obese individuals are at a higher risk of cardiovascular events compared to lean subjects, recent studies in patients with acute myocardial infarction (AMI) have suggested that obesity may exert protective effects (the "obesity paradox"). We sough...

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Published inRevista clínica espanõla (English edition) Vol. 214; no. 3; p. 113
Main Authors Arrebola-Moreno, A L, Marfil-Alvarez, R, Catena, A, García-Retamero, R, Arrebola, J P, Melgares-Moreno, R, Ramirez-Hernández, J A, Kaski, J C
Format Journal Article
LanguageEnglish
Published Spain 01.04.2014
Subjects
Acute Coronary Syndrome - epidemiology
Acute Coronary Syndrome - etiology
Adult
Aged
Aged, 80 and over
Body Mass Index
Cross-Sectional Studies
Female
Humans
Linear Models
Male
Middle Aged
Myocardium - pathology
Obesity - epidemiology
Overweight - epidemiology
Risk Factors
Síndrome coronario agudo
Paradoja de la obesidad
Obesity paradox
Puntuación BARI
Acute coronary syndrome
Acute myocardial infarction
BARI score
Infarto agudo de miocardio
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ISSN2254-8874
2254-8874
DOI10.1016/j.rce.2013.12.004

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Summary:Whilst traditional studies have shown that obese individuals are at a higher risk of cardiovascular events compared to lean subjects, recent studies in patients with acute myocardial infarction (AMI) have suggested that obesity may exert protective effects (the "obesity paradox"). We sought to assess the relationship between body mass index (BMI) and the BARI score (BARIsc), a validated tool used to assess myocardium at risk, in patients with acute coronary syndrome. Participants were 116 consecutive patients (mean age, 60.6 years; 97 men) with AMI (68 ST elevated myocardial infarction, STEMI; 48 non-ST elevated myocardial infarction, NSTEMI). Demographics, BMI, risk factors, biochemistry data, left ventricular function, angiographic data and the BARIsc were assessed in every patient. Multiple linear regression analyses showed that BMI significantly correlated with BARIsc; β=.23, p<0.02. This was found only in the overweight/obese patients, β=.27, p<0.01, but not in patients with normal BMIs, β=0.08, p=0.71. An increased body weight is associated with an increased area of myocardium at risk in patients with ACS.
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ISSN:2254-8874
2254-8874
DOI:10.1016/j.rce.2013.12.004