Overall and cause-specific survival for patients undergoing lobectomy, near-total, or total thyroidectomy for differentiated thyroid cancer

• Published in: Head & neck Vol. 33; no. 5; pp. 645 - 649
• Main Authors: Barney, Brandon M., Hitchcock, Ying J., Sharma, Pramod, Shrieve, Dennis C., Tward, Jonathan D.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.05.2011; Wiley
• Subjects: Adenocarcinoma, Follicular - mortality; Adenocarcinoma, Follicular - pathology; Adenocarcinoma, Follicular - surgery; Age Factors; Biological and medical sciences; Carcinoma, Papillary - mortality; Carcinoma, Papillary - pathology; Carcinoma, Papillary - surgery; Endocrinopathies; extent of resection; Female; follicular thyroid cancer; Humans; Lymphatic Metastasis; Male; Malignant tumors; Medical sciences; Middle Aged; Multivariate Analysis; Otorhinolaryngology. Stomatology; papillary thyroid cancer; prognostic factors; Registries; SEER Program; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of endocrine glands; survival; Thyroid Neoplasms - mortality; Thyroid Neoplasms - pathology; Thyroid Neoplasms - surgery; Thyroid. Thyroid axis (diseases); Thyroidectomy - methods; Thyroidectomy - statistics & numerical data; United States - epidemiology; United States; Endocrinopathy; Human; Prognosis; extent of resection; Stomatology; Thyroid diseases; Surgical resection; ENT; prognostic factors; Malignant tumor; Survival; Thyroidectomy; follicular thyroid cancer; Thyroid cancer; Treatment; Surgery; papillary thyroid cancer; Lobectomy; Cancer
• ISSN: 1043-3074; 1097-0347; 1097-0347
• DOI: 10.1002/hed.21504

Background The extent of surgery for well‐differentiated thyroid cancer remains controversial. The purpose of this study was to evaluate the type of resection, age, T classification, nodal status, tumor size, and year of diagnosis for overall survival (OS) and cause‐specific survival (CSS) using a large database. Methods Using the Surveillance, Epidemiology, and End Results (SEER) database, 23,605 subjects were identified with papillary or follicular thyroid cancer between 1983 and 2002. OS and CSS were estimated, and outcomes for local excision, lobectomy, near‐total thyroidectomy, or total thyroidectomy were compared. Results Ten‐year OS and CSS by surgery were: total thyroidectomy, 90.4% and 96.8%, respectively; near‐total thyroidectomy, 89.5% and 96.6%, respectively; and lobectomy, 90.8% and 98.6%, respectively. Controlling for risk factors, near‐total thyroidectomy was inferior to total thyroidectomy for OS (hazard ratio [HR] 1.21; p = .019) and CSS (HR 1.39; p = .019). Age, T3/T4 disease, positive nodes, and tumor size were associated with poorer outcomes. Conclusion Total thyroidectomy resulted in improved survival. Therapy should be individualized, accounting for potential complications and recurrence patterns. © 2010 Wiley Periodicals, Inc. Head Neck, 2011