Partition coefficients for gadolinium chelates in the normal myocardium: Comparison of gadopentetate dimeglumine and gadobenate dimeglumine

• Published in: Journal of magnetic resonance imaging Vol. 36; no. 3; pp. 733 - 737
• Main Authors: Kawel, Nadine, Nacif, Marcelo, Santini, Francesco, Liu, Songtao, Bremerich, Jens, Arai, Andrew E., Bluemke, David A.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.09.2012
• Subjects: Adult; Chelating Agents - pharmacokinetics; Computer Simulation; Contrast Media - pharmacokinetics; gadobenate dimeglumine; Gadolinium DTPA - pharmacokinetics; gadopentetate dimeglumine; Humans; Image Interpretation, Computer-Assisted - methods; Magnetic Resonance Imaging - methods; Meglumine - analogs & derivatives; Meglumine - pharmacokinetics; Metabolic Clearance Rate; Models, Cardiovascular; modified Look-Locker inversion recovery; modified Look‐Locker inversion recovery, partition coefficient; Myocardium - metabolism; Myocardium - pathology; Organometallic Compounds - pharmacokinetics; partition coefficient; Reproducibility of Results; Sensitivity and Specificity; T1 mapping
• ISSN: 1053-1807; 1522-2586; 1522-2586
• DOI: 10.1002/jmri.23651

Purpose: To evaluate the influence of contrast agents with different relaxivity on the partition coefficient (λ) and timing of equilibration using a modified Look‐Locker inversion recovery (MOLLI) sequence in cardiac magnetic resonance imaging (MRI). Materials and Methods: MOLLI was acquired in 20 healthy subjects (1.5T) at the mid‐ventricular short axis precontrast and 5, 10, 20, 25, and 30 minutes after administration of a bolus of 0.15 mmol/kg gadobenate dimeglumine (Gd‐BOPTA) (n = 10) or gadopentetate dimeglumine (Gd‐DTPA) (n = 10). T1 times were measured in myocardium and blood pool. λ was approximated by ΔR1myocardium/ΔR1blood. Values for Gd‐BOPTA and Gd‐DTPA were compared. Interobserver agreement was evaluated (intraclass correlation coefficient [ICC]). Results: T1 times of myocardium and blood pool (P < 0.001) and λ (0.42 ± 0.03 and 0.47 ± 0.04, respectively, P < 0.001; excluding 5 minutes for Gd‐BOPTA) were significantly lower for Gd‐BOPTA than Gd‐DTPA. The λ(Gd‐DTPA) showed no significant variation between 5 and 30 minutes. The λ(Gd‐BOPTA) values were significantly lower at 5 minutes compared to other times (0.38 vs. 0.42; P < 0.05). Interobserver agreement for λ values was excellent with Gd‐BOPTA (ICC = 0.818) and good for Gd‐DTPA (ICC = 0.631). Conclusion: The λ(Gd‐BOPTA) values were significantly lower compared to λ(Gd‐DTPA) at the same administered dose. Using Gd‐BOPTA, the equilibrium between myocardium and blood pool was not achieved at 5 minutes postcontrast. J. Magn. Reson. Imaging 2012;36:733–737. © 2012 Wiley Periodicals, Inc.